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  • Quinazoline alpha-adrenoreceptor blockers as an adjunct cancer treatment: From bench to bedside

    Author(s)
    King, Liam
    Christie, David
    Dare, Wendy
    Bernaitis, Nijole
    Chess-Williams, Russ
    McDermott, Catherine
    Forbes, Amanda
    Anoopkumar-Dukie, Shailendra
    Griffith University Author(s)
    Anoopkumar-Dukie, Shailendra
    Bernaitis, Nijole L.
    Christie, David R.
    King, Liam D.
    Chess-Williams, Russ
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    Drug repurposing has been increasingly used by both researchers and clinicians to identify new cancer treatments. The alpha-1 adrenoreceptor blockers are a class of drugs that have been used for many years in the treatment of hypertension and benign prostatic hyperplasia. Some of the drugs in this class, notably the quinazoline derivatives, have been found to display cytotoxic properties, identifying them as potential options in the treatment of cancer. This review will examine the currently available evidence that investigates the cytotoxic and anti-cancer properties of these agents, the mechanisms behind these properties ...
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    Drug repurposing has been increasingly used by both researchers and clinicians to identify new cancer treatments. The alpha-1 adrenoreceptor blockers are a class of drugs that have been used for many years in the treatment of hypertension and benign prostatic hyperplasia. Some of the drugs in this class, notably the quinazoline derivatives, have been found to display cytotoxic properties, identifying them as potential options in the treatment of cancer. This review will examine the currently available evidence that investigates the cytotoxic and anti-cancer properties of these agents, the mechanisms behind these properties and how the alpha-1 blockers fit within current cancer therapies. It aims to answer the question of whether these agents can go from the laboratory bench top into cancer clinics.
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    Journal Title
    European Journal of Pharmacology
    Volume
    893
    DOI
    https://doi.org/10.1016/j.ejphar.2020.173831
    Note
    This publication has been entered as an advanced online version in Griffith Research Online.
    Subject
    Artificial Intelligence and Image Processing
    Psychology
    Cognitive Sciences
    Pharmacology and Pharmaceutical Sciences
    Alpha blocker
    Cancer
    Chemotherapy
    Drug repurposing
    Radiotherapy
    Publication URI
    http://hdl.handle.net/10072/400629
    Collection
    • Journal articles

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