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  • Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer

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    Tan443288-Published.pdf (1.754Mb)
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    Version of Record (VoR)
    Author(s)
    Tan, Kah Ni
    Avery, Vicky M
    Carrasco-Pozo, Catalina
    Griffith University Author(s)
    Tan, Kah Ni
    Avery, Vicky M.
    Carrasco Pozo, Catalina A.
    Year published
    2020
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    Abstract
    Androgen receptor (AR)-mediated signaling is essential for the growth and differentiation of the normal prostate and is the primary target for androgen deprivation therapy in prostate cancer. Tat interactive protein 60 kDa (Tip60) is a histone acetyltransferase that is critical for AR activation. It is well known that cancer cells rewire their metabolic pathways in order to sustain aberrant proliferation. Growing evidence demonstrates that the AR and Tip60 modulate key metabolic processes to promote the survival of prostate cancer cells, in addition to their classical roles. AR activation enhances glucose metabolism, including ...
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    Androgen receptor (AR)-mediated signaling is essential for the growth and differentiation of the normal prostate and is the primary target for androgen deprivation therapy in prostate cancer. Tat interactive protein 60 kDa (Tip60) is a histone acetyltransferase that is critical for AR activation. It is well known that cancer cells rewire their metabolic pathways in order to sustain aberrant proliferation. Growing evidence demonstrates that the AR and Tip60 modulate key metabolic processes to promote the survival of prostate cancer cells, in addition to their classical roles. AR activation enhances glucose metabolism, including glycolysis, tricarboxylic acid cycle and oxidative phosphorylation, as well as lipid metabolism in prostate cancer. The AR also interacts with other metabolic regulators, including calcium/calmodulin-dependent kinase kinase 2 and mammalian target of rapamycin. Several studies have revealed the roles of Tip60 in determining cell fate indirectly by modulating metabolic regulators, such as c-Myc, hypoxia inducible factor 1α (HIF-1α) and p53 in various cancer types. Furthermore, Tip60 has been shown to regulate the activity of key enzymes in gluconeogenesis and glycolysis directly through acetylation. Overall, both the AR and Tip60 are master metabolic regulators that mediate cellular energy metabolism in prostate cancer, providing a framework for the development of novel therapeutic targets in androgen-dependent prostate cancer. View Full-Text
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    Journal Title
    International Journal of Molecular Sciences
    Volume
    21
    Issue
    18
    DOI
    https://doi.org/10.3390/ijms21186622
    Copyright Statement
    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Other Chemical Sciences
    Genetics
    Other Biological Sciences
    Science & Technology
    Life Sciences & Biomedicine
    Physical Sciences
    Biochemistry & Molecular Biology
    Chemistry, Multidisciplinary
    Publication URI
    http://hdl.handle.net/10072/400854
    Collection
    • Journal articles

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