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dc.contributor.authorTan, Kah Ni
dc.contributor.authorAvery, Vicky M
dc.contributor.authorCarrasco-Pozo, Catalina
dc.date.accessioned2021-01-11T02:05:28Z
dc.date.available2021-01-11T02:05:28Z
dc.date.issued2020
dc.identifier.issn1661-6596
dc.identifier.doi10.3390/ijms21186622
dc.identifier.urihttp://hdl.handle.net/10072/400854
dc.description.abstractAndrogen receptor (AR)-mediated signaling is essential for the growth and differentiation of the normal prostate and is the primary target for androgen deprivation therapy in prostate cancer. Tat interactive protein 60 kDa (Tip60) is a histone acetyltransferase that is critical for AR activation. It is well known that cancer cells rewire their metabolic pathways in order to sustain aberrant proliferation. Growing evidence demonstrates that the AR and Tip60 modulate key metabolic processes to promote the survival of prostate cancer cells, in addition to their classical roles. AR activation enhances glucose metabolism, including glycolysis, tricarboxylic acid cycle and oxidative phosphorylation, as well as lipid metabolism in prostate cancer. The AR also interacts with other metabolic regulators, including calcium/calmodulin-dependent kinase kinase 2 and mammalian target of rapamycin. Several studies have revealed the roles of Tip60 in determining cell fate indirectly by modulating metabolic regulators, such as c-Myc, hypoxia inducible factor 1α (HIF-1α) and p53 in various cancer types. Furthermore, Tip60 has been shown to regulate the activity of key enzymes in gluconeogenesis and glycolysis directly through acetylation. Overall, both the AR and Tip60 are master metabolic regulators that mediate cellular energy metabolism in prostate cancer, providing a framework for the development of novel therapeutic targets in androgen-dependent prostate cancer. View Full-Text
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMDPI
dc.relation.ispartofpagefrom6622
dc.relation.ispartofissue18
dc.relation.ispartofjournalInternational Journal of Molecular Sciences
dc.relation.ispartofvolume21
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchOther biological sciences
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode3199
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsChemistry, Multidisciplinary
dc.titleMetabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationTan, KN; Avery, VM; Carrasco-Pozo, C, Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer, International Journal of Molecular Sciences, 2020, 21 (18), pp. 6622
dcterms.dateAccepted2020-09-09
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-01-11T02:03:07Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorTan, Kah Ni
gro.griffith.authorAvery, Vicky M.
gro.griffith.authorCarrasco Pozo, Catalina A.


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