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dc.contributor.authorTefera, Yonas G
dc.contributor.authorGebresillassie, Begashaw M
dc.contributor.authorMekuria, Abebe B
dc.contributor.authorAbebe, Tamrat B
dc.contributor.authorErku, Daniel A
dc.contributor.authorSeid, Nurahmed
dc.contributor.authorBeshir, Habiba B
dc.date.accessioned2021-01-11T04:40:56Z
dc.date.available2021-01-11T04:40:56Z
dc.date.issued2017
dc.identifier.issn2052-1707en_US
dc.identifier.urihttp://hdl.handle.net/10072/400874
dc.description.abstractMost of the medications which are currently used for the treatment of childhood diseases are either not licensed or being prescribed outside the terms of the product license (off-label prescribing). This study aimed at determining the extent of unlicensed and off-label drug uses and associated factors in children hospitalized in Gondar University Referral Hospital, Northwest Ethiopia. An institution-based prospective cross-sectional study was employed from April 15 to July 15, 2016. A total of 243 pediatric patients admitted to Gondar university referral hospital were included in the study using simple random sampling method. Data were collected using structured questionnaire, and the data collected were entered and analyzed using Statistical Packages for Social Sciences (SPSS) version 20. From the total of 800 drugs prescribed, 607 (75.8%) were off-label. Off-label medicine use was frequently observed in antimicrobials (60.6%) followed by central nervous system drugs (14.3%). The extent off-label prescribing was highest in age group of 6-13 years (30%). Inappropriate dosing and frequency (42.3%) were the most common reason for off-label medicine use. Having other variables controlled, age group and undergoing surgical procedure remained to be significant predictors of off-label prescribing in the multivariate regression analysis. Implementing evidence-based approach in prescribing by generating more quality literatures on the safety profile and effectiveness of off-label would improve the injudicious use of drugs in pediatric population.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherWileyen_US
dc.publisher.urihttps://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.304en_US
dc.relation.ispartofpagefrome00304en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalPharmacology Research & Perspectivesen_US
dc.relation.ispartofvolume5en_US
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistryen_US
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciencesen_US
dc.subject.fieldofresearchcode0304en_US
dc.subject.fieldofresearchcode1115en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsPharmacology & Pharmacyen_US
dc.subject.keywordsChildrenen_US
dc.subject.keywordsEthiopiaen_US
dc.titleOff-label drug use in hospitalized children: a prospective observational study at Gondar University Referral Hospital, Northwestern Ethiopiaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationTefera, YG; Gebresillassie, BM; Mekuria, AB; Abebe, TB; Erku, DA; Seid, N; Beshir, HB, Off-label drug use in hospitalized children: a prospective observational study at Gondar University Referral Hospital, Northwestern Ethiopia, Pharmacology Research & Perspectives, 2017, 5 (2), pp. e00304en_US
dcterms.dateAccepted2017-02-14
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-01-11T04:37:34Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2017 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
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gro.griffith.authorErku, Daniel


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