• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • CBTp for people with treatment refractory schizophrenia on clozapine: a systematic review and meta-analysis

    Author(s)
    Todorovic, Aleksandar
    Lal, Sweta
    Dark, Frances
    De Monte, Veronica
    Kisely, Steve
    Siskind, Dan
    Griffith University Author(s)
    Kisely, Steve R.
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    Background: Cognitive behavioural therapy for psychosis (CBTp), an effective treatment for people with schizophrenia, may have a role in clozapine refractory schizophrenia. Aims: A systematic-review and meta-analysis on the impact of CBTp on psychotic symptoms in people on clozapine. Methods: We searched PubMed, Embase, PsycInfo, CINAHL and Cochrane for randomised control trials of CBTp as augmentation in people with treatment-refractory schizophrenia on clozapine and conducted pair-wise meta-analyses. Results: Four studies met inclusion criteria. On pairwise meta-analyses, the primary outcome of total psychotic symptoms was ...
    View more >
    Background: Cognitive behavioural therapy for psychosis (CBTp), an effective treatment for people with schizophrenia, may have a role in clozapine refractory schizophrenia. Aims: A systematic-review and meta-analysis on the impact of CBTp on psychotic symptoms in people on clozapine. Methods: We searched PubMed, Embase, PsycInfo, CINAHL and Cochrane for randomised control trials of CBTp as augmentation in people with treatment-refractory schizophrenia on clozapine and conducted pair-wise meta-analyses. Results: Four studies met inclusion criteria. On pairwise meta-analyses, the primary outcome of total psychotic symptoms was not significantly altered by CBTp at either therapy endpoint or six to twelve months follow-up. Secondary outcomes showed that CBT improved positive symptoms at both therapy endpoint (SMD −0.33, 95%CI −0.50 to −0.16, p = 0.002, I2 = 0%) and six to twelve months follow-up (SMD −0.20, 95%CI −0.38 to −0.02, p = 0.03, I2 = 0%) though did not alter negative psychotic symptoms at either timepoint. Conclusions: CBTp may lead to small benefits for positive symptoms refractory to clozapine. Given the low risks associated with CBTp, and the limited alternative options for clozapine refractory schizophrenia, this approach should be considered in this population.
    View less >
    Journal Title
    Journal of Mental Health
    DOI
    https://doi.org/10.1080/09638237.2020.1836558
    Note
    This publication has been entered as an advanced online version in Griffith Research Online.
    Subject
    Clinical Sciences
    Psychology
    Social Sciences
    Psychology, Clinical
    Treatment refractory schizophrenia
    clozapine
    Publication URI
    http://hdl.handle.net/10072/400896
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander