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  • Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy

    Author(s)
    Shrestha, Nirajan
    Ezechukwu, Henry C
    Holland, Olivia J
    Hryciw, Deanne H
    Griffith University Author(s)
    Shrestha, Nirajan
    Holland, Olivia J.
    Skelly, Deanne
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    Obesity is an increasing global health epidemic that affects all ages, including women of reproductive age. During pregnancy, maternal obesity is associated with adverse pregnancy outcomes that lead to complications for the mother. In addition, maternal obesity can increase the risk of poor perinatal outcomes for the infant due to altered development. Recent research has investigated the effects of maternal obesity on peripheral organ development and health in later life in offspring. In this review, we have summarized studies that investigated the programming effects of maternal obesity before and during pregnancy on ...
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    Obesity is an increasing global health epidemic that affects all ages, including women of reproductive age. During pregnancy, maternal obesity is associated with adverse pregnancy outcomes that lead to complications for the mother. In addition, maternal obesity can increase the risk of poor perinatal outcomes for the infant due to altered development. Recent research has investigated the effects of maternal obesity on peripheral organ development and health in later life in offspring. In this review, we have summarized studies that investigated the programming effects of maternal obesity before and during pregnancy on metabolic, cardiovascular, immune, and microbiome perturbations in offspring. Epidemiological studies investigating the effects of maternal obesity on offspring development can be complex due to other copathologies and genetic diversity. Animal studies have provided some insights into the specific mechanisms and pathways involved in programming peripheral disease risk. The effects of maternal obesity during pregnancy on offspring development are often sex specific, with sex-specific changes in placental transport and function suggestive that this organ is likely to play a central role. We believe that this review will assist in facilitating future investigations regarding the underlying mechanisms that link maternal obesity and offspring disease risk in peripheral organs.
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    Journal Title
    American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
    Volume
    319
    Issue
    5
    DOI
    https://doi.org/10.1152/ajpregu.00214.2020
    Subject
    Biological Sciences
    Medical and Health Sciences
    Science & Technology
    Life Sciences & Biomedicine
    Physiology
    fetal programming
    maternal overnutrition
    Publication URI
    http://hdl.handle.net/10072/400920
    Collection
    • Journal articles

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