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dc.contributor.authorCarey, Alison
dc.contributor.authorCunningham, Kelly
dc.contributor.authorHafner, Louise
dc.contributor.authorTimms, Peter
dc.contributor.authorBeagley, Kenneth
dc.date.accessioned2017-05-03T15:52:59Z
dc.date.available2017-05-03T15:52:59Z
dc.date.issued2009
dc.date.modified2011-08-19T06:42:25Z
dc.identifier.issn14401711
dc.identifier.doi10.1038/icb.2009.3
dc.identifier.urihttp://hdl.handle.net/10072/40094
dc.description.abstractChlamydia trachomatis infections have been implicated in problems such as pelvic inflammatory disease and infertility in females. Although there are some studies examining the kinetics of ascending infection, there is limited information on the kinetics of pathology development and cellular infiltrate into the reproductive tissues in relation to the effects of inoculating dose, and a better understanding of these is needed. The murine model of female genital tract Chlamydia muridarum infection is frequently used as a model of human C. trachomatis reproductive tract infection. To investigate the kinetics of ascending genital infection and associated pathology development, female BALB/c mice were intravaginally infected with C. muridarum at doses ranging from 5 נ102 to 2.6 נ106 inclusion forming units. We found that the inoculating dose affects the course of infection and the ascension of bacteria, with the highest dose ascending rapidly to the oviducts. By comparison, the lowest dose resulted in the greatest bacterial load in the lower reproductive tract. Interestingly, we found that the dose did not significantly affect inflammatory cell infiltrate in the various regions. Overall, this data show the effects of infectious dose on the kinetics of ascending chlamydial infection and associated inflammatory infiltration in BALB/c mice.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom337
dc.relation.ispartofpageto343
dc.relation.ispartofissue4
dc.relation.ispartofjournalImmunology and Cell Biology
dc.relation.ispartofvolume87
dc.rights.retentionY
dc.subject.fieldofresearchInfectious Agents
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode060502
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1107
dc.titleEffects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorCarey, Alison


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