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  • Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection

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    Engwerda457752Published.pdf (2.328Mb)
    Author(s)
    Chan, Jo-Anne
    Loughland, Jessica R
    de Labastida Rivera, Fabian
    SheelaNair, Arya
    Andrew, Dean W
    Dooley, Nicholas L
    Wines, Bruce D
    Amante, Fiona H
    Webb, Lachlan
    Hogarth, P Mark
    McCarthy, James S
    Beeson, James G
    Engwerda, Christian R
    Boyle, Michelle J
    Griffith University Author(s)
    Engwerda, Christian R.
    Year published
    2020
    Metadata
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    Abstract
    CD4+ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, the activation of Tfh is restricted to the Th1 subset and not associated with antibody levels. To identify Tfh subsets that are associated with antibody development in malaria, we assess Tfh and antibodies longitudinally in human volunteers with experimental P. falciparum infection. Tfh cells activate during infection, with distinct dynamics in different Tfh subsets. Th2-Tfh cells activate early, during peak infection, while Th1-Tfh cells activate 1 week after peak infection and treatment. Th2-Tfh ...
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    CD4+ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, the activation of Tfh is restricted to the Th1 subset and not associated with antibody levels. To identify Tfh subsets that are associated with antibody development in malaria, we assess Tfh and antibodies longitudinally in human volunteers with experimental P. falciparum infection. Tfh cells activate during infection, with distinct dynamics in different Tfh subsets. Th2-Tfh cells activate early, during peak infection, while Th1-Tfh cells activate 1 week after peak infection and treatment. Th2-Tfh cell activation is associated with the functional breadth and magnitude of parasite antibodies. In contrast, Th1-Tfh activation is not associated with antibody development but instead with plasma cells, which have previously been shown to play a detrimental role in the development of long-lived immunity. Thus, our study identifies the contrasting roles of Th2 and Th1-Tfh cells during experimental P. falciparum malaria.
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    Journal Title
    Cell Reports Medicine
    Volume
    1
    Issue
    9
    DOI
    https://doi.org/10.1016/j.xcrm.2020.100157
    Copyright Statement
    © 2020 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Microbiology
    CHMI
    IBSM
    T follicular helper cells
    antibodies
    experimental infection
    Publication URI
    http://hdl.handle.net/10072/401097
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