Show simple item record

dc.contributor.authorMcKay, Leanne C.
dc.contributor.authorAdams, Lewis
dc.contributor.authorFrackowiak, Richard S. J.
dc.contributor.authorCorfield, Douglas R.
dc.date.accessioned2017-05-03T13:56:58Z
dc.date.available2017-05-03T13:56:58Z
dc.date.issued2008
dc.date.modified2011-08-19T06:43:05Z
dc.identifier.issn10538119
dc.identifier.doi10.1016/j.neuroimage.2008.01.058
dc.identifier.urihttp://hdl.handle.net/10072/40109
dc.description.abstractFew tasks are simpler to perform than a breath hold; however, the neural basis underlying this voluntary inhibitory behaviour, which must suppress spontaneous respiratory motor output, is unknown. Here, using blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI), we investigated the neural network responsible for volitional breath holding in 8 healthy humans. BOLD images of the whole brain (156 brain volumes, voxel resolution 3 נ3 נ3 mm) were acquired every 5.2 s. All breath holds were performed for 15 s at resting expiratory lung volume when respiratory musculature was presumed to be relaxed, which ensured that the protocol highlighted the inhibitory components underlying the breath hold. An experimental paradigm was designed to dissociate the time course of the whole-brain BOLD signal from the time course of the local, neural-related BOLD signal associated with the inhibitory task. We identified a bilateral network of cortical and subcortical structures including the insula, basal ganglia, frontal cortex, parietal cortex and thalamus, which are in common with response inhibition tasks, and in addition, activity within the pons. From these results we speculate that the pons has a role in integrating information from supra-brainstem structures, and in turn it exerts an inhibitory effect on medullary respiratory neurones to inhibit breathing during breath holding.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAcademic Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1824
dc.relation.ispartofpageto1832
dc.relation.ispartofissue4
dc.relation.ispartofjournalNeuroImage
dc.relation.ispartofvolume40
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchCentral nervous system
dc.subject.fieldofresearchSystems physiology
dc.subject.fieldofresearchMedical physiology not elsewhere classified
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320903
dc.subject.fieldofresearchcode320803
dc.subject.fieldofresearchcode320899
dc.subject.fieldofresearchcode52
dc.titleA bilateral cortico-bulbar network associated with breath holding in humans, determined by functional magnetic resonance imaging
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorAdams, Lewis


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record