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dc.contributor.authorC. McKay, Leanneen_US
dc.contributor.authorAdams, Lewisen_US
dc.contributor.authorS.J. Frackowiak, Richarden_US
dc.contributor.authorR. Corfield, Douglasen_US
dc.date.accessioned2017-04-24T11:10:53Z
dc.date.available2017-04-24T11:10:53Z
dc.date.issued2008en_US
dc.date.modified2011-08-19T06:43:05Z
dc.identifier.issn10538119en_US
dc.identifier.doi10.1016/j.neuroimage.2008.01.058en_AU
dc.identifier.urihttp://hdl.handle.net/10072/40109
dc.description.abstractFew tasks are simpler to perform than a breath hold; however, the neural basis underlying this voluntary inhibitory behaviour, which must suppress spontaneous respiratory motor output, is unknown. Here, using blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI), we investigated the neural network responsible for volitional breath holding in 8 healthy humans. BOLD images of the whole brain (156 brain volumes, voxel resolution 3 נ3 נ3 mm) were acquired every 5.2 s. All breath holds were performed for 15 s at resting expiratory lung volume when respiratory musculature was presumed to be relaxed, which ensured that the protocol highlighted the inhibitory components underlying the breath hold. An experimental paradigm was designed to dissociate the time course of the whole-brain BOLD signal from the time course of the local, neural-related BOLD signal associated with the inhibitory task. We identified a bilateral network of cortical and subcortical structures including the insula, basal ganglia, frontal cortex, parietal cortex and thalamus, which are in common with response inhibition tasks, and in addition, activity within the pons. From these results we speculate that the pons has a role in integrating information from supra-brainstem structures, and in turn it exerts an inhibitory effect on medullary respiratory neurones to inhibit breathing during breath holding.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAcademic Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1824en_US
dc.relation.ispartofpageto1832en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalNeuroImageen_US
dc.relation.ispartofvolume40en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMedical Physiology not elsewhere classifieden_US
dc.subject.fieldofresearchSystems Physiologyen_US
dc.subject.fieldofresearchCentral Nervous Systemen_US
dc.subject.fieldofresearchcode111699en_US
dc.subject.fieldofresearchcode111603en_US
dc.subject.fieldofresearchcode110903en_US
dc.titleA bilateral cortico-bulbar network associated with breath holding in humans, determined by functional magnetic resonance imagingen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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