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dc.contributor.authorPerkins, Anthonyen_US
dc.date.accessioned2017-04-24T08:09:21Z
dc.date.available2017-04-24T08:09:21Z
dc.date.issued2011en_US
dc.date.modified2011-08-19T06:43:27Z
dc.identifier.issn22107789en_US
dc.identifier.doi10.1016/j.preghy.2010.10.008en_AU
dc.identifier.urihttp://hdl.handle.net/10072/40113
dc.description.abstractThere is considerable evidence that placental oxidative stress plays a significant role in the etiology of preeclampsia. Prophylactic use of exogenous anti-oxidants such as vitamins E and C have proven to be ineffective and potentially dangerous. The current study addresses the role of endogenous anti-oxidant systems in preeclampsia. In particular, data on the selenodependent enzymes glutathione peroxidase and thioredoxin reductase will be presented and the role of selenium in preeclampsia will be considered. The aim of these studies was to determine the levels of endogenous antioxidants, selenium, and biological oxidation in normal and preeclamptic placental tissues. Furthermore, animal studies were conducted to assess the impact of selenium depletion on anti-oxidant expression and activity, oxidative stress and symptoms of preeclampsia. Selenium depletion generated placental oxidative stress and produced a preeclamptic like syndrome in pregnant rats suggesting a link between placental oxidative stress, endogenous antioxidant disequilibria and the pathogenesis of preeclampsia that may be linked to insufficient dietary selenium. The selenium of status of preeclamptic mothers was also considered and lower levels of selenium were observed when compared to normal controls. Selenium supplementation improves endogenous anti-oxidant expression in trophoblast cells and might provide an effective method of protecting the placenta from oxidative stress during preeclampsia. Clinical studies are now underway to investigate the benefits of low dose selenium supplementation on the development and progression of preeclampsia.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom95en_US
dc.relation.ispartofpageto99en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalPregnancy Hypertensionen_US
dc.relation.ispartofvolume1en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchObstetrics and Gynaecologyen_US
dc.subject.fieldofresearchcode270199en_US
dc.subject.fieldofresearchcode111402en_US
dc.titlePlacental Oxidative Stress, Selenium and Preeclampsiaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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