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dc.contributor.authorZhang, Ping
dc.contributor.authorLee, Jason S
dc.contributor.authorGartlan, Kate H
dc.contributor.authorSchuster, Iona S
dc.contributor.authorComerford, Iain
dc.contributor.authorVarelias, Antiopi
dc.contributor.authorUllah, Md Ashik
dc.contributor.authorVuckovic, Slavica
dc.contributor.authorKoyama, Motoko
dc.contributor.authorKuns, Rachel D
dc.contributor.authorLocke, Kelly R
dc.contributor.authorBeckett, Kirrilee J
dc.contributor.authorOlver, Stuart D
dc.contributor.authorSamson, Luke D
dc.contributor.authoret al.
dc.date.accessioned2021-01-15T04:47:12Z
dc.date.available2021-01-15T04:47:12Z
dc.date.issued2017
dc.identifier.issn2470-9468
dc.identifier.doi10.1126/sciimmunol.aah7152
dc.identifier.urihttp://hdl.handle.net/10072/401156
dc.description.abstractType 1 regulatory T (TR1) cells are Foxp3- interleukin-10 (IL-10)-producing CD4+ T cells with potent immunosuppressive properties, but their requirements for lineage development have remained elusive. We show that TR1 cells constitute the most abundant regulatory population after allogeneic bone marrow transplantation (BMT), express the transcription factor Eomesodermin (Eomes), and are critical for the prevention of graft-versus-host disease. We demonstrate that Eomes is required for TR1 cell differentiation, during which it acts in concert with the transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) by transcriptionally activating IL-10 expression and repressing differentiation into other T helper cell lineages. We further show that Eomes induction in TR1 cells requires T-bet and donor macrophage-derived IL-27. Thus, we define the cellular and transcriptional control of TR1 cell differentiation during BMT, opening new avenues to therapeutic manipulation.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherThe American Association for the Advancement of Science (AAAS)
dc.relation.ispartofpagefromeaah7152
dc.relation.ispartofissue10
dc.relation.ispartofjournalScience Immunology
dc.relation.ispartofvolume2
dc.subject.fieldofresearchEnvironmental sciences
dc.subject.fieldofresearchcode41
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsImmunology
dc.subject.keywordsVERSUS-HOST-DISEASE
dc.subject.keywordsTRANSCRIPTION FACTORS BLIMP-1
dc.titleEomesodermin promotes the development of type 1 regulatory T (T(R)1) cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationZhang, P; Lee, JS; Gartlan, KH; Schuster, IS; Comerford, I; Varelias, A; Ullah, MA; Vuckovic, S; Koyama, M; Kuns, RD; Locke, KR; Beckett, KJ; Olver, SD; Samson, LD; et al.; Engwerda, CR; Degli-Esposti, MA; Kallies, A; Tey, S-K; Hill, GR, Eomesodermin promotes the development of type 1 regulatory T (T(R)1) cells, Science Immunology, 2017, 2 (10), pp. eaah7152
dcterms.dateAccepted2017-02-22
dc.date.updated2021-01-15T04:39:01Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© The Author(s) 2017. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 2017, 2 (10), pp. eaah7152, DOI: https://dx.doi.org/10.1126/sciimmunol.aah7152.
gro.hasfulltextFull Text
gro.griffith.authorEngwerda, Christian R.


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