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  • Targeted Molecular Imaging of Cardiovascular Diseases by Iron Oxide Nanoparticles

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    Ta456338Accepted.pdf (784.5Kb)
    Author(s)
    Vazquez-Prada, Karla X
    Lam, Jacinta
    Kamato, Danielle
    Ping Xu, Zhi
    Little, Peter J
    Ta, Hang T
    Griffith University Author(s)
    Ta, Hang
    Xu, Gordon
    Kamato, Danielle
    Year published
    2020
    Metadata
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    Abstract
    Cardiovascular disease is one of the major contributors to global disease burden. Atherosclerosis is an inflammatory process that involves the accumulation of lipids and fibrous elements in the large arteries, forming an atherosclerotic plaque. Rupture of unstable plaques leads to thrombosis that triggers life-threatening complications such as myocardial infarction. Current diagnostic methods are invasive as they require insertion of a catheter into the coronary artery. Molecular imaging techniques, such as magnetic resonance imaging, have been developed to image atherosclerotic plaques and thrombosis due to its high spatial ...
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    Cardiovascular disease is one of the major contributors to global disease burden. Atherosclerosis is an inflammatory process that involves the accumulation of lipids and fibrous elements in the large arteries, forming an atherosclerotic plaque. Rupture of unstable plaques leads to thrombosis that triggers life-threatening complications such as myocardial infarction. Current diagnostic methods are invasive as they require insertion of a catheter into the coronary artery. Molecular imaging techniques, such as magnetic resonance imaging, have been developed to image atherosclerotic plaques and thrombosis due to its high spatial resolution and safety. The sensitivity of magnetic resonance imaging can be improved with contrast agents, such as iron oxide nanoparticles. This review presents the most recent advances in atherosclerosis, thrombosis, and myocardial infarction molecular imaging using iron oxide-based nanoparticles. While some studies have shown their effectiveness, many are yet to undertake comprehensive testing of biocompatibility. There are still potential hazards to address and complications to diagnosis, therefore strategies for overcoming these challenges are required.
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    Journal Title
    Arteriosclerosis, Thrombosis, and Vascular Biology
    DOI
    https://doi.org/10.1161/ATVBAHA.120.315404
    Copyright Statement
    © 2020 American Heart Association, Inc. . This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Cardiovascular medicine and haematology
    Clinical sciences
    atherosclerosis
    cardiovascular diseases
    magnetic resonance imaging
    molecular imaging
    thrombosis
    Publication URI
    http://hdl.handle.net/10072/401234
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    • Journal articles

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