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  • CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa

    Author(s)
    A.Cunningham, Kelly
    J. Carey, Alison
    Lycke, Nils
    Timms, Peter
    W. Beagley, Kenneth
    Griffith University Author(s)
    Carey, Alison
    Year published
    2009
    Metadata
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    Abstract
    Chlamydia trachomatis is a significant human pathogen with potentially severe disease sequelae in the genital tract, including infertility. A successful vaccine will need to effectively target immunity to the genital mucosa. Intranasal immunisation with cholera toxin (CT) can target immunity to the genital tract, but has the potential to cause neurological side effects. CTA1-DD is a non-toxic potent mucosal adjuvant which combines the enzymatic properties of CT, with a B cell targeting moiety. Here, we demonstrate that intranasal immunisation with CTA1-DD and chlamydial Major Outer Membrane Protein (MOMP) results in the ...
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    Chlamydia trachomatis is a significant human pathogen with potentially severe disease sequelae in the genital tract, including infertility. A successful vaccine will need to effectively target immunity to the genital mucosa. Intranasal immunisation with cholera toxin (CT) can target immunity to the genital tract, but has the potential to cause neurological side effects. CTA1-DD is a non-toxic potent mucosal adjuvant which combines the enzymatic properties of CT, with a B cell targeting moiety. Here, we demonstrate that intranasal immunisation with CTA1-DD and chlamydial Major Outer Membrane Protein (MOMP) results in the induction of neutralising systemic and mucosal antibodies, and reduces the level of chlamydial shedding following intravaginal challenge with Chlamydia muridarum. Thus, CTA1-DD is an effective adjuvant for vaccine development against Chlamydia trachomatis, and possibly also a range of other genital pathogens.
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    Journal Title
    Journal of Reproductive Immunology
    Volume
    81
    Issue
    1
    DOI
    https://doi.org/10.1016/j.jri.2009.04.002
    Subject
    Immunology not elsewhere classified
    Immunology
    Paediatrics and Reproductive Medicine
    Publication URI
    http://hdl.handle.net/10072/40125
    Collection
    • Journal articles

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