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dc.contributor.authorParkin, Donald Maxwell
dc.contributor.authorYoulden, Danny R
dc.contributor.authorChitsike, Inam
dc.contributor.authorChokunonga, Eric
dc.contributor.authorCouitchéré, Line
dc.contributor.authorGnahatin, Franck
dc.contributor.authorNambooze, Sarah
dc.contributor.authorWabinga, Henry
dc.contributor.authorAitken, Joanne F
dc.date.accessioned2021-01-19T00:40:07Z
dc.date.available2021-01-19T00:40:07Z
dc.date.issued2021
dc.identifier.issn0020-7136
dc.identifier.doi10.1002/ijc.33468
dc.identifier.urihttp://hdl.handle.net/10072/401268
dc.description.abstractThe lack of accurate population-based information on childhood cancer stage and survival in low-income countries is a barrier to improving childhood cancer outcomes. In this study, data from three population-based registries in sub-Saharan Africa (Abidjan, Harare and Kampala) were examined for children aged under 15. We assessed the feasibility of assigning stage at diagnosis according to Tier 1 of the Toronto Childhood Cancer Stage Guidelines for patients with non-Hodgkin lymphoma (including Burkitt lymphoma), retinoblastoma and Wilms tumour. Patients were actively followed-up, allowing calculation of three-year relative survival by cancer type and registry. Stage-specific observed survival was estimated. The cohort comprised 381 children, of whom half (n = 192, 50%) died from any cause within three years of diagnosis. Three-year relative survival varied by malignancy and location and ranged from 17% (95% Confidence Interval [CI] 6-33%) for Burkitt lymphoma in Harare to 57% (95% CI 31-76%) for retinoblastoma in Kampala. Stage was assigned for 83% of patients (n = 317 of 381), with over half having metastatic or advanced disease at diagnosis (n = 166, 52%). Stage was a strong predictor of survival for each malignancy; for example, three-year observed survival was 88% (95% CI 68%-96%) and 13% (4%-29%) for localised and advanced Burkitt lymphoma, respectively (P < 0.001). These are the first data on stage distribution and stage-specific survival for childhood cancers in Africa. They demonstrate the feasibility of the Toronto Stage Guidelines in a low-resource setting and highlight the value of population-based cancer registries in aiding our understanding of the poor outcomes experienced by this population.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofjournalInternational Journal of Cancer
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1112
dc.subject.keywordschildhood cancers; sub-Saharan Africa
dc.subject.keywordsregistry
dc.subject.keywordsstage
dc.titleStage at diagnosis and survival by stage for the leading childhood cancers in three populations of sub-Saharan Africa
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationParkin, DM; Youlden, DR; Chitsike, I; Chokunonga, E; Couitchéré, L; Gnahatin, F; Nambooze, S; Wabinga, H; Aitken, JF, Stage at diagnosis and survival by stage for the leading childhood cancers in three populations of sub-Saharan Africa, International Journal of Cancer, 2021
dcterms.dateAccepted2020-12-03
dc.date.updated2021-01-19T00:15:56Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.rights.copyright© 2021 UICC. This is the peer reviewed version of the following article: Stage at diagnosis and survival by stage for the leading childhood cancers in three populations of sub-Saharan Africa, International Journal of Cancer, 2021, which has been published in final form at https://doi.org/10.1002/ijc.33468. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorYoulden, Danny R.
gro.griffith.authorAitken, Joanne


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