dc.contributor.author | Parkin, Donald Maxwell | |
dc.contributor.author | Youlden, Danny R | |
dc.contributor.author | Chitsike, Inam | |
dc.contributor.author | Chokunonga, Eric | |
dc.contributor.author | Couitchéré, Line | |
dc.contributor.author | Gnahatin, Franck | |
dc.contributor.author | Nambooze, Sarah | |
dc.contributor.author | Wabinga, Henry | |
dc.contributor.author | Aitken, Joanne F | |
dc.date.accessioned | 2021-01-19T00:40:07Z | |
dc.date.available | 2021-01-19T00:40:07Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0020-7136 | |
dc.identifier.doi | 10.1002/ijc.33468 | |
dc.identifier.uri | http://hdl.handle.net/10072/401268 | |
dc.description.abstract | The lack of accurate population-based information on childhood cancer stage and survival in low-income countries is a barrier to improving childhood cancer outcomes. In this study, data from three population-based registries in sub-Saharan Africa (Abidjan, Harare and Kampala) were examined for children aged under 15. We assessed the feasibility of assigning stage at diagnosis according to Tier 1 of the Toronto Childhood Cancer Stage Guidelines for patients with non-Hodgkin lymphoma (including Burkitt lymphoma), retinoblastoma and Wilms tumour. Patients were actively followed-up, allowing calculation of three-year relative survival by cancer type and registry. Stage-specific observed survival was estimated. The cohort comprised 381 children, of whom half (n = 192, 50%) died from any cause within three years of diagnosis. Three-year relative survival varied by malignancy and location and ranged from 17% (95% Confidence Interval [CI] 6-33%) for Burkitt lymphoma in Harare to 57% (95% CI 31-76%) for retinoblastoma in Kampala. Stage was assigned for 83% of patients (n = 317 of 381), with over half having metastatic or advanced disease at diagnosis (n = 166, 52%). Stage was a strong predictor of survival for each malignancy; for example, three-year observed survival was 88% (95% CI 68%-96%) and 13% (4%-29%) for localised and advanced Burkitt lymphoma, respectively (P < 0.001). These are the first data on stage distribution and stage-specific survival for childhood cancers in Africa. They demonstrate the feasibility of the Toronto Stage Guidelines in a low-resource setting and highlight the value of population-based cancer registries in aiding our understanding of the poor outcomes experienced by this population. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofjournal | International Journal of Cancer | |
dc.subject.fieldofresearch | Oncology and carcinogenesis | |
dc.subject.fieldofresearchcode | 3211 | |
dc.subject.keywords | childhood cancers; sub-Saharan Africa | |
dc.subject.keywords | registry | |
dc.subject.keywords | stage | |
dc.title | Stage at diagnosis and survival by stage for the leading childhood cancers in three populations of sub-Saharan Africa | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Parkin, DM; Youlden, DR; Chitsike, I; Chokunonga, E; Couitchéré, L; Gnahatin, F; Nambooze, S; Wabinga, H; Aitken, JF, Stage at diagnosis and survival by stage for the leading childhood cancers in three populations of sub-Saharan Africa, International Journal of Cancer, 2021 | |
dcterms.dateAccepted | 2020-12-03 | |
dc.date.updated | 2021-01-19T00:15:56Z | |
dc.description.version | Accepted Manuscript (AM) | |
gro.description.notepublic | This publication has been entered as an advanced online version in Griffith Research Online. | |
gro.rights.copyright | © 2021 UICC. This is the peer reviewed version of the following article: Stage at diagnosis and survival by stage for the leading childhood cancers in three populations of sub-Saharan Africa, International Journal of Cancer, 2021, which has been published in final form at https://doi.org/10.1002/ijc.33468. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html) | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Youlden, Danny R. | |
gro.griffith.author | Aitken, Joanne | |