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dc.contributor.authorJ. Mann, Neilen_US
dc.contributor.authorL. O⿿Connell, Stellaen_US
dc.contributor.authorM. Baldwin, Kylieen_US
dc.contributor.authorSingh, Induen_US
dc.contributor.authorJ. Meyer, Barbaraen_US
dc.date.accessioned2017-05-03T15:57:24Z
dc.date.available2017-05-03T15:57:24Z
dc.date.issued2010en_US
dc.date.modified2011-08-19T06:44:22Z
dc.identifier.issn00244201en_US
dc.identifier.doi10.1007/s11745-010-3450-zen_AU
dc.identifier.urihttp://hdl.handle.net/10072/40136
dc.description.abstractFish are a rich source of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two long-chain polyunsaturated n-3 fatty acids (LC n-3 PUFA) with cardiovascular benefits. A related but less-investigated LC n-3 PUFA, docosapentaenoic acid (DPA), is more common in seal oil and pasture-fed red meats. This study compared indicators of platelet function and plasma lipids in healthy volunteers given supplements containing these different fatty acids (FA) for 14 days. Subjects, randomised into three groups of ten, consumed capsules of tuna oil (210 mg EPA, 30 mg DPA, 810 mg DHA), seal oil (340 mg EPA, 230 mg DPA, 450 mg DHA) or placebo (sunola) oil. Supplementary LC n-3 PUFA levels were approximately 1 g/day in both fish and seal oil groups. Baseline dietary FA and other nutrient intakes were similar in all groups. Both fish and seal oil elevated platelet DHA levels (P < 0.01). Seal oil also raised platelet DPA and EPA levels (P < 0.01), and decreased p-selectin (P = 0.01), a platelet activation marker negatively associated with DPA (P = 0.03) and EPA (P < 0.01) but not DHA. Plasma triacylglycerol decreased (P = 0.03) and HDL-cholesterol levels increased (P = 0.01) with seal oil only. Hence, seal oil may be more efficient than fish oil at promoting healthy plasma lipid profiles and lowering thrombotic risk, possibly due to its high DPA as well as EPA content.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringeren_US
dc.publisher.placeGermanyen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom669en_US
dc.relation.ispartofpageto681en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalLipidsen_US
dc.relation.ispartofvolume45en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchCardiovascular Medicine and Haematology not elsewhere classifieden_US
dc.subject.fieldofresearchcode110299en_US
dc.titleEffects of Seal Oil and Tuna-Fish Oil on Platelet Parameters and Plasma Lipid Levels in Healthy Subjectsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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