A clinically relevant model of stroke using aged rats
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Author(s)
Popa-Wagner, A
Popescu-Driga, M
Pinosanu, LR
Grigore, M
Ghinea, FS
Capitanescu, B
Hermann, DM
Griffith University Author(s)
Year published
2020
Metadata
Show full item recordAbstract
Diabetes, arterial hypertension and hypercholesterolemia are commonly described in elderly persons and are associated with higher risk of stroke. Therefore, it is of paramount importance to test the efficacy of cell therapies in an age-appropriate animal stroke model. Unfortunately, at the present time, animal models of stroke ignore age and comorbidities frequently associated with aging. Thus, numerous bench-to-bedside translation experiments evaluating neuroprotective strategies have been unsuccessful. In order to mimic more closely the clinical condition, we have established a model of ischemic stroke in aged rats. Using ...
View more >Diabetes, arterial hypertension and hypercholesterolemia are commonly described in elderly persons and are associated with higher risk of stroke. Therefore, it is of paramount importance to test the efficacy of cell therapies in an age-appropriate animal stroke model. Unfortunately, at the present time, animal models of stroke ignore age and comorbidities frequently associated with aging. Thus, numerous bench-to-bedside translation experiments evaluating neuroprotective strategies have been unsuccessful. In order to mimic more closely the clinical condition, we have established a model of ischemic stroke in aged rats. Using this model, we have showed that post-stroke angiogenesis is not impaired in the ischemic aged brain. Also, we have proved that stroke in aged rodent models reiterates closely the chain of pathological and clinical events described in stroke patients.
View less >
View more >Diabetes, arterial hypertension and hypercholesterolemia are commonly described in elderly persons and are associated with higher risk of stroke. Therefore, it is of paramount importance to test the efficacy of cell therapies in an age-appropriate animal stroke model. Unfortunately, at the present time, animal models of stroke ignore age and comorbidities frequently associated with aging. Thus, numerous bench-to-bedside translation experiments evaluating neuroprotective strategies have been unsuccessful. In order to mimic more closely the clinical condition, we have established a model of ischemic stroke in aged rats. Using this model, we have showed that post-stroke angiogenesis is not impaired in the ischemic aged brain. Also, we have proved that stroke in aged rodent models reiterates closely the chain of pathological and clinical events described in stroke patients.
View less >
Journal Title
Vascular Cell
Volume
12
Issue
1
Copyright Statement
© 2020, Aurel Popa-Wagner, Mircea Popescu-Driga, Leonard-Radu Pinosanu, Monica Grigore, Flavia Semida Ghinea, Bogdan Capitanescu, Dirk M Hermann. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Subject
Biochemistry and cell biology
Cardiovascular medicine and haematology
Oncology and carcinogenesis