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dc.contributor.authorPopa-Wagner, A
dc.contributor.authorPopescu-Driga, M
dc.contributor.authorPinosanu, LR
dc.contributor.authorGrigore, M
dc.contributor.authorGhinea, FS
dc.contributor.authorCapitanescu, B
dc.contributor.authorHermann, DM
dc.date.accessioned2021-01-21T22:36:26Z
dc.date.available2021-01-21T22:36:26Z
dc.date.issued2020
dc.identifier.issn2045-824X
dc.identifier.doi10.24238/13221-12-1-198
dc.identifier.urihttp://hdl.handle.net/10072/401409
dc.description.abstractDiabetes, arterial hypertension and hypercholesterolemia are commonly described in elderly persons and are associated with higher risk of stroke. Therefore, it is of paramount importance to test the efficacy of cell therapies in an age-appropriate animal stroke model. Unfortunately, at the present time, animal models of stroke ignore age and comorbidities frequently associated with aging. Thus, numerous bench-to-bedside translation experiments evaluating neuroprotective strategies have been unsuccessful. In order to mimic more closely the clinical condition, we have established a model of ischemic stroke in aged rats. Using this model, we have showed that post-stroke angiogenesis is not impaired in the ischemic aged brain. Also, we have proved that stroke in aged rodent models reiterates closely the chain of pathological and clinical events described in stroke patients.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPubliverse Online S.R.L
dc.relation.ispartofpagefrom6
dc.relation.ispartofissue1
dc.relation.ispartofjournalVascular Cell
dc.relation.ispartofvolume12
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode3211
dc.titleA clinically relevant model of stroke using aged rats
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPopa-Wagner, A; Popescu-Driga, M; Pinosanu, LR; Grigore, M; Ghinea, FS; Capitanescu, B; Hermann, DM, A clinically relevant model of stroke using aged rats, Vascular Cell, 2020, 12 (1), pp. 6
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-01-21T22:02:58Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020, Aurel Popa-Wagner, Mircea Popescu-Driga, Leonard-Radu Pinosanu, Monica Grigore, Flavia Semida Ghinea, Bogdan Capitanescu, Dirk M Hermann. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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gro.griffith.authorPopa-Wagner, Aurel


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