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dc.contributor.authorDhanani, JA
dc.contributor.authorGoodman, S
dc.contributor.authorAhern, B
dc.contributor.authorCohen, J
dc.contributor.authorFraser, JF
dc.contributor.authorBarnett, A
dc.contributor.authorDiab, S
dc.contributor.authorBhatt, M
dc.contributor.authorRoberts, JA
dc.date.accessioned2021-01-28T22:28:22Z
dc.date.available2021-01-28T22:28:22Z
dc.date.issued2020
dc.identifier.issn0924-8579
dc.identifier.doi10.1016/j.ijantimicag.2020.106232
dc.identifier.urihttp://hdl.handle.net/10072/401513
dc.description.abstractBackground: Ventilator-associated pneumonia is common and is treated using nebulized antibiotics. Although adequate pulmonary biodistribution is important for antibiotic effect, there is a lack of data for both intravenous (IV) and nebulized antibiotic administration during mechanical ventilation. Objective: To describe the comparative pulmonary regional distribution of IV and nebulized technetium-99m-labeled tobramycin (99mTc-tobramycin) 400 mg in a mechanically-ventilated ovine model. Methods: The study was performed in a mechanically-ventilated ovine model. 99mTc-tobramycin 400 mg was obtained using a radiolabeling process. Computed tomography (CT) was performed. Ten sheep were given 99mTc-tobramycin 400 mg via either an IV (five sheep) or nebulized (five sheep) route. Planar images (dorsal, ventral, left lateral and right lateral) were obtained using a gamma camera. Blood samples were obtained every 15 min for 1 h (4 time points) and lung, liver, both kidney, and urine samples were obtained post-mortem. Results: Ten sheep were anesthetized and mechanically ventilated. Whole-lung deposition of nebulized 99mTc-tobramycin 400 mg was significantly lower than with IV (8.8% vs. 57.1%, P<0.001). For both administration routes, there was significantly lower deposition in upper lung zones compared with the rest of the lungs. Dorsal deposition was significantly higher with nebulized 99mTc-tobramycin 400 mg compared with IV (68.9% vs. 58.9%, P=0.003). Lung concentrations of 99mTc-tobramycin were higher with IV compared with nebulized administration. There were significantly higher concentrations of 99mTc-tobramycin in blood, liver and urine with IV administration compared with nebulized. Conclusions: Nebulization resulted in lower whole and regional lung deposition of 99mTc-tobramycin compared with IV administration and appeared to be associated with low blood and extra-pulmonary organ concentrations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofpagefrom106232
dc.relation.ispartofissue2
dc.relation.ispartofjournalInternational Journal of Antimicrobial Agents
dc.relation.ispartofvolume57
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3207
dc.subject.fieldofresearchcode3214
dc.subject.keywords(99m)Tc-tobramycin
dc.subject.keywordsnebulized antibiotics
dc.subject.keywordsplanar scintigraphy
dc.subject.keywordspulmonary biodistribution
dc.subject.keywordstissue quantification
dc.titleComparative lung distribution of radiolabeled tobramycin between nebulized and intravenous administration in a mechanically-ventilated ovine model, an observational study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDhanani, JA; Goodman, S; Ahern, B; Cohen, J; Fraser, JF; Barnett, A; Diab, S; Bhatt, M; Roberts, JA, Comparative lung distribution of radiolabeled tobramycin between nebulized and intravenous administration in a mechanically-ventilated ovine model, an observational study, International Journal of Antimicrobial Agents, 2020, 57 (2), pp. 106232
dcterms.dateAccepted2020-11-14
dc.date.updated2021-01-28T22:00:06Z
gro.hasfulltextNo Full Text
gro.griffith.authorFraser, John F.


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