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dc.contributor.authorArababadi, Mohammad Kazemi
dc.contributor.authorAbousaidi, Hamid
dc.contributor.authorHassanshahi, Gholamhossein
dc.contributor.authorPourfathollah, Ali Akbar
dc.contributor.authorDaneshmandi, Saeed
dc.contributor.authorAkbarpour, Vajihe
dc.contributor.authorHakimi, Hamid
dc.contributor.authorKennedy, Derek
dc.date.accessioned2017-11-27T12:00:27Z
dc.date.available2017-11-27T12:00:27Z
dc.date.issued2011
dc.date.modified2011-08-26T09:00:16Z
dc.identifier.issn2008-3866
dc.identifier.urihttp://hdl.handle.net/10072/40152
dc.description.abstractObjective(s) Deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. Vitamin D3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. The aim of this study was to investigate the association between polymorphisms in intron 8 and exon 9 of the vitamin D receptor (VDR) and this disease. Materials and Methods This study was performed on 100 asthmatic patients and 100 healthy controls. PCR-RFLP was performed to examine polymorphisms in intron 8 and exon 9 of VDR gene. Results Our results showed a statistically significant difference in the Taq-1 evaluated genotypes of exon 9 of the VDR gene when comparing healthy patients to asthmatic patients. Conclusion Based on our results, it can be concluded that VDR and its functional polymorphisms may play an important role in the pathogenesis of asthma.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent74094 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherMashhad University of Medical Sciences
dc.publisher.placeIran
dc.publisher.urihttp://www.mums.ac.ir/shares/basic_medical/basicmedjou/2011/may/a5.pdf
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom225
dc.relation.ispartofpageto230
dc.relation.ispartofissue3
dc.relation.ispartofjournalIranian Journal of Basic Medical Sciences
dc.relation.ispartofvolume14
dc.rights.retentionY
dc.subject.fieldofresearchMedical Genetics (excl. Cancer Genetics)
dc.subject.fieldofresearchHumoural Immunology and Immunochemistry
dc.subject.fieldofresearchcode110311
dc.subject.fieldofresearchcode110705
dc.titlePolymorphisms within Exon 9, But Not Intron 8, of the Vitamin D Receptor Gene Are Associated with Asthma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2011 Mashhad University of Medical Sciences. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorKennedy, Derek D.


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