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  • Building A Biofoundry

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    Rourke459593Accepted.pdf (1.386Mb)
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    Version of Record (VoR)
    Author(s)
    Holowko, Maciej B
    Frow, Emma K
    Reid, Janet C
    Rourke, Michelle
    Vickers, Claudia E
    Griffith University Author(s)
    Rourke, Michelle F.
    Year published
    2020
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    Abstract
    A biofoundry provides automation and analytics infrastructure to support the engineering of biological systems. It allows scientists to perform synthetic biology and aligned experimentation on a high-throughput scale, massively increasing the solution space that can be examined for any given problem or question. However, establishing a biofoundry is a challenging undertaking, with numerous technical and operational considerations that must be addressed. Using collated learnings, here we outline several considerations that should be addressed prior to and during establishment. These include drivers for establishment, institutional ...
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    A biofoundry provides automation and analytics infrastructure to support the engineering of biological systems. It allows scientists to perform synthetic biology and aligned experimentation on a high-throughput scale, massively increasing the solution space that can be examined for any given problem or question. However, establishing a biofoundry is a challenging undertaking, with numerous technical and operational considerations that must be addressed. Using collated learnings, here we outline several considerations that should be addressed prior to and during establishment. These include drivers for establishment, institutional models, funding and revenue models, personnel, hardware and software, data management, interoperability, client engagement, and biosecurity issues. The high cost of establishment and operation means that developing a long-term business model for biofoundry sustainability in the context of funding frameworks, actual and potential client base, and costing structure is critical. Moreover, since biofoundries are leading a conceptual shift in experimental design for bioengineering, sustained outreach and engagement with the research community is needed to grow the client base. Recognition of the significant, long-term financial investment required and an understanding of the complexities of operationalization is critical for a sustainable biofoundry venture. To ensure state-of-the-art technology is integrated into planning, extensive engagement with existing facilities and community groups, such as the Global Biofoundries Alliance, is recommended.
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    Journal Title
    Synthetic Biology
    DOI
    https://doi.org/10.1093/synbio/ysaa026
    Copyright Statement
    © Crown copyright 2020. This article contains public sector information licensed under the Open Government Licence v3.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/), which permits unrestricted distribution and reproduction in any medium, adaptation and exploitation of the information, providing that you acknowledge the source of the Information in your product or application by including or linking to any attribution statement specified by the Information Provider(s) and, where possible, provide a link to this licence.
    Subject
    Other biological sciences
    Synthetic biology
    Publication URI
    http://hdl.handle.net/10072/401650
    Collection
    • Journal articles

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