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  • Measuring inflammatory foot disease in rheumatoid arthritis: development and validation of the Rheumatoid Arthritis Foot Disease Activity Index‐5

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    Author(s)
    Hoque, Anika
    Gallagher, Kellie
    McEntegart, Anne
    Porter, Duncan
    Steultjens, Martijn
    Woodburn, James
    Hendry, Gordon J
    Griffith University Author(s)
    Woodburn, Jim
    Year published
    2020
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    Abstract
    Objective Omission of foot joints from composite global disease activity indices may lead to underestimation of foot and overall disease in rheumatoid arthritis (RA) and under‐treatment. The aim of this study was to evaluate the measurement properties of the Rheumatoid Arthritis Foot Disease Activity Index‐5 (RADAI‐F5), a newly developed patient‐reported outcome measure for capturing foot disease activity in people with RA. Methods Participants with RA self‐completed the RADAI‐F5, modified Rheumatoid Arthritis Disease Activity Index (mRADAI‐5), Foot Function Index (FFI) and Foot Impact Scale impairment/footwear and ...
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    Objective Omission of foot joints from composite global disease activity indices may lead to underestimation of foot and overall disease in rheumatoid arthritis (RA) and under‐treatment. The aim of this study was to evaluate the measurement properties of the Rheumatoid Arthritis Foot Disease Activity Index‐5 (RADAI‐F5), a newly developed patient‐reported outcome measure for capturing foot disease activity in people with RA. Methods Participants with RA self‐completed the RADAI‐F5, modified Rheumatoid Arthritis Disease Activity Index (mRADAI‐5), Foot Function Index (FFI) and Foot Impact Scale impairment/footwear and activity/participation subscales (FIS‐IF and FIS‐AP). The 28 joint Disease Activity Score (DAS28‐ESR) was also recorded. Subgroups completed the RADAI‐F5 at 1 week and 6‐months. Psychometric properties including construct, content, and longitudinal validity, internal consistency, 1‐week reproducibility, and responsiveness over 6‐months were evaluated. Results Of 142 respondents, 103 were female, with a mean (standard deviation [SD]) age of 55 years (12.5) and median (interquartile range [IQR]) RA disease duration of 10 (3.6‐20.8) months. Theoretically consistent associations confirming construct validity were observed with mRADAI‐5 (0.789, 95% confidence interval [CI] 0.73‐0.85), FFI (0.713, CI 0.62‐0.79) and FIS‐IF (0.695, CI 0.66‐0.82) (p<0.001); FFI‐AP (0.478, p<0.001, CI 0.37‐0.63) and the DAS28‐ESR (0.379, p<0.001, CI 0.26‐0.57). The RADAI‐F5 demonstrated high internal consistency (Cronbach’s Alpha=0.90) and good reproducibility (ICC=0.868, p<0.001, CI 0.80‐0.91; smallest detectable change=2.69). Content validity was confirmed with 82% rating the instrument relevant and easy to understand. Conclusion The Rheumatoid Arthritis Foot Disease Activity Index‐5 is a valid, reliable, responsive, clinically feasible PROM for measuring foot disease activity in RA.
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    Journal Title
    Arthritis Care & Research
    DOI
    https://doi.org/10.1002/acr.24259
    Copyright Statement
    © 2020 Wiley-Liss, Inc., A Wiley Company. This is the peer reviewed version of the following article: Measuring inflammatory foot disease in rheumatoid arthritis: development and validation of the Rheumatoid Arthritis Foot Disease Activity Index‐5, Arthritis Care and Research, 2020, which has been published in final form at https://doi.org/10.1002/acr.24259. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Note
    This publication has been entered as an advanced online version in Griffith Research Online.
    Subject
    Clinical sciences
    Health services and systems
    Public health
    Psychology
    Publication URI
    http://hdl.handle.net/10072/401658
    Collection
    • Journal articles

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