Show simple item record

dc.contributor.authorFrear, Cody
dc.contributor.authorGriffin, Bronwyn R
dc.date.accessioned2021-02-05T03:54:51Z
dc.date.available2021-02-05T03:54:51Z
dc.date.issued2020
dc.identifier.issn1559-047X
dc.identifier.doi10.1093/jbcr/iraa024.055
dc.identifier.urihttp://hdl.handle.net/10072/401751
dc.description.abstractIntroduction In the setting of burns, negative pressure wound therapy (NPWT) has been widely adopted as a means of wound bed preparation prior to skin grafting and graft immobilization. Its role in the treatment of acute burns has been less well-studied, although there is limited evidence to suggest that it might facilitate physiological healing. This study aimed to assess its efficacy in the management of acute burns in children with small-to-medium-sized thermal injuries. Methods In this single-center, two-arm, parallel, randomized, controlled clinical trial, we assigned patients under 17 years of age with acute thermal burns covering < 5% of their total body surface area to either an active control (nanocrystalline silver dressings) or an experimental treatment combining standard dressings with NPWT. Patients were excluded if their burn occurred >7 days prior to presentation, affected the face, or was deemed by clinicians to be trivial. The primary outcome was time to re-epithelialization. Secondary outcomes included scarring, grafting, pain, ease of management, and adverse events. Results A total of 114 children underwent randomization. The median time to re-epithelialization was 8 days (interquartile range (IQR) 7–10) for the NPWT group and 10 days (IQR 8–12.25) for the control group (hazard ratio, 1.515; 95% confidence interval (CI) 1.003 to 2.289; P=0.048). Children administered NPWT within 48 hours of their injury (n=16) re-epithelialized in a median of 7 days (IQR 5–8; HR, 2.129; 95% CI 1.155 to 3.922; P=0.015). The proportion of children referred to scar management was 8.7% for the experimental group and 25.9% for the control group (odds ratio, 0.27; 95% CI 0.08 to 0.90; P=0.032). There were no significant differences in grafting (2.2% vs. 7.4%; odds ratio, 0.28; 95% CI 0.03 to 2.58; P=0.260), pain during dressing changes (P=0.946), or at-home pain between dressing changes (P=0.592). NPWT was associated with a greater treatment burden (P< 0.001) and incidence of adverse events, which included minor blistering and wound maceration. Conclusions In children with small-to-medium-sized thermal burns, NPWT accelerated re-epithelialization and decreased the need for long-term scar management.
dc.description.peerreviewedYes
dc.languageen
dc.publisherOxford University Press (OUP)
dc.relation.ispartofpagefromS34
dc.relation.ispartofpagetoS34
dc.relation.ispartofissueSupplement_1
dc.relation.ispartofjournalJournal of Burn Care & Research
dc.relation.ispartofvolume41
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.titleNegative Pressure Wound Therapy for Small-to-medium-sized Paediatric Thermal Burns: A Randomized Controlled Trial (SONATA in C)
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationFrear, C; Griffin, BR, Negative Pressure Wound Therapy for Small-to-medium-sized Paediatric Thermal Burns: A Randomized Controlled Trial (SONATA in C), Journal of Burn Care & Research, 2020, 41 (Supplement_1), pp. S34-S34
dc.date.updated2021-02-05T03:50:39Z
gro.hasfulltextNo Full Text
gro.griffith.authorGriffin, Bronwyn R.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record