Dielectrophoresis enrichment with built-in capacitive sensor microfluidic platform for tumor rare cell detection

Abstract

This paper presents a dielectrophoresis (DEP) enrichment microfluidic platform with built-in anti-bodybased capacitive sensor for tumor rare cells detection. We take the advantages of the effective DEP actuation, the high selectivity property of antibody for rare cell immobilization, and the high sensitivity of differential capacitive sensing for quantitatively reading out, to produce advanced platform, toward single tumor cell detection for the rapid laboratory tests of cancers diagnoses and other metabolic diseases applications.