Efficacy and Effectiveness of a 23-Valent Polysaccharide Vaccine Against Invasive and Non-Invasive Pneumococcal Disease and Related Outcomes: A Review of Available Evidence
Author(s)
Niederman, Michael S
Folaranmi, Temitope
Buchwald, Ulrike K
Musey, Luwy
Cripps, Allan W
Johnson, Kelly D
Griffith University Author(s)
Year published
2021
Metadata
Show full item recordAbstract
Introduction: Routine pneumococcal vaccination for adults aged ≥60 or ≥65 years and those with underlying at-risk and high-risk conditions is recommended in many countries. However, studies estimating the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) have revealed mixed results, explained, in part, by variability in study design and endpoints used to assess outcomes.Areas covered: The authors conducted a literature review of independently randomized trials and real-world studies published from 2010-2020 that assessed the effectiveness and efficacy of PPSV23 against vaccine-type or any-serotype ...
View more >Introduction: Routine pneumococcal vaccination for adults aged ≥60 or ≥65 years and those with underlying at-risk and high-risk conditions is recommended in many countries. However, studies estimating the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) have revealed mixed results, explained, in part, by variability in study design and endpoints used to assess outcomes.Areas covered: The authors conducted a literature review of independently randomized trials and real-world studies published from 2010-2020 that assessed the effectiveness and efficacy of PPSV23 against vaccine-type or any-serotype invasive and non-invasive pneumococcal disease in adults aged ≥60 years. The authors also evaluated differences in study design that may contribute to the heterogeneity of available evidence.Expert opinion: Policy decisions regarding the inclusion of vaccines into national immunization plans should be made taking the quality and limitations of studies into account. This review shows that PPSV23 is effective against vaccine-type invasive pneumococcal disease and vaccine-type pneumococcal pneumonia. It can also lower the burden of vaccine-type pneumococcal pneumonia. PPSV23-conferred protection may be lower in adults aged ≥75 years, those with certain underlying conditions, and individuals who were vaccinated >5 years before disease onset. This is an important finding that supports the benefit of PPSV23 vaccination for older adults.
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View more >Introduction: Routine pneumococcal vaccination for adults aged ≥60 or ≥65 years and those with underlying at-risk and high-risk conditions is recommended in many countries. However, studies estimating the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) have revealed mixed results, explained, in part, by variability in study design and endpoints used to assess outcomes.Areas covered: The authors conducted a literature review of independently randomized trials and real-world studies published from 2010-2020 that assessed the effectiveness and efficacy of PPSV23 against vaccine-type or any-serotype invasive and non-invasive pneumococcal disease in adults aged ≥60 years. The authors also evaluated differences in study design that may contribute to the heterogeneity of available evidence.Expert opinion: Policy decisions regarding the inclusion of vaccines into national immunization plans should be made taking the quality and limitations of studies into account. This review shows that PPSV23 is effective against vaccine-type invasive pneumococcal disease and vaccine-type pneumococcal pneumonia. It can also lower the burden of vaccine-type pneumococcal pneumonia. PPSV23-conferred protection may be lower in adults aged ≥75 years, those with certain underlying conditions, and individuals who were vaccinated >5 years before disease onset. This is an important finding that supports the benefit of PPSV23 vaccination for older adults.
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Journal Title
Expert Rev Vaccines
Note
This publication has been entered as an advanced online version in Griffith Research Online.
Subject
Clinical sciences
Health services and systems
Public health
23-valent pneumococcal polysaccharide vaccine
at-risk
high-risk
invasive pneumococcal disease
older adults