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  • Efficacy and Effectiveness of a 23-Valent Polysaccharide Vaccine Against Invasive and Non-Invasive Pneumococcal Disease and Related Outcomes: A Review of Available Evidence

    Author(s)
    Niederman, Michael S
    Folaranmi, Temitope
    Buchwald, Ulrike K
    Musey, Luwy
    Cripps, Allan W
    Johnson, Kelly D
    Griffith University Author(s)
    Cripps, Allan W.
    Year published
    2021
    Metadata
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    Abstract
    Introduction: Routine pneumococcal vaccination for adults aged ≥60 or ≥65 years and those with underlying at-risk and high-risk conditions is recommended in many countries. However, studies estimating the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) have revealed mixed results, explained, in part, by variability in study design and endpoints used to assess outcomes.Areas covered: The authors conducted a literature review of independently randomized trials and real-world studies published from 2010-2020 that assessed the effectiveness and efficacy of PPSV23 against vaccine-type or any-serotype ...
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    Introduction: Routine pneumococcal vaccination for adults aged ≥60 or ≥65 years and those with underlying at-risk and high-risk conditions is recommended in many countries. However, studies estimating the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) have revealed mixed results, explained, in part, by variability in study design and endpoints used to assess outcomes.Areas covered: The authors conducted a literature review of independently randomized trials and real-world studies published from 2010-2020 that assessed the effectiveness and efficacy of PPSV23 against vaccine-type or any-serotype invasive and non-invasive pneumococcal disease in adults aged ≥60 years. The authors also evaluated differences in study design that may contribute to the heterogeneity of available evidence.Expert opinion: Policy decisions regarding the inclusion of vaccines into national immunization plans should be made taking the quality and limitations of studies into account. This review shows that PPSV23 is effective against vaccine-type invasive pneumococcal disease and vaccine-type pneumococcal pneumonia. It can also lower the burden of vaccine-type pneumococcal pneumonia. PPSV23-conferred protection may be lower in adults aged ≥75 years, those with certain underlying conditions, and individuals who were vaccinated >5 years before disease onset. This is an important finding that supports the benefit of PPSV23 vaccination for older adults.
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    Journal Title
    Expert Rev Vaccines
    DOI
    https://doi.org/10.1080/14760584.2021.1880328
    Note
    This publication has been entered as an advanced online version in Griffith Research Online.
    Subject
    Clinical Sciences
    Public Health and Health Services
    23-valent pneumococcal polysaccharide vaccine
    at-risk
    high-risk
    invasive pneumococcal disease
    older adults
    Publication URI
    http://hdl.handle.net/10072/401788
    Collection
    • Journal articles

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