dc.contributor.author | Fadhil, Rushdi | |
dc.contributor.author | Wei, Ming | |
dc.contributor.author | Nikolarakos, Dimitrios | |
dc.contributor.author | Good, David | |
dc.contributor.author | Nair, Raj | |
dc.date.accessioned | 2021-02-09T05:33:56Z | |
dc.date.available | 2021-02-09T05:33:56Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | http://hdl.handle.net/10072/401907 | |
dc.description.abstract | Objectives: To determine whether salivary miR-3928 can be used for early head and neck cancer diagnostic purpose.
Methods: The expression level of human salivary miR-3928 was investigated in 230 supernatant saliva samples. These samples were collected from head and neck squamous cell carcinoma (HNSCC) patients (n = 150) and healthy individuals (n = 80). Quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) was used to detect the expression level of the miRNA.
Results: Total RNA was isolated in average 160 ng/µl from 500 µl of supernatant saliva. Overall, miR-3928 expression was revealed to be correlated with HNC. We found that salivary miR-3928 was significantly down regulated in supernatant saliva of HNC patients (P< 0.05).
Conclusions: This study reported that down-regulate of miR-3928 could be used as salivary biomarker for HNSCC detection. | |
dc.publisher | International Association of Dental Research (IADR) | |
dc.publisher.uri | https://iadr.abstractarchives.com/abstract/19iags-3185831/mir-3928-in-saliva-as-potential-biomarker-for-head-and-neck-squamous-cell-carcinoma | |
dc.relation.ispartofconferencename | 97th International Association of Dental Research (IADR) General Session | |
dc.relation.ispartofconferencetitle | 97th International Association of Dental Research (IADR) General Session | |
dc.relation.ispartofdatefrom | 2019-06-19 | |
dc.relation.ispartofdateto | 2019-06-22 | |
dc.relation.ispartoflocation | Vancouver, Canada | |
dc.subject.fieldofresearch | Oncology and carcinogenesis | |
dc.subject.fieldofresearchcode | 3211 | |
dc.title | Mir-3928 in Saliva as Potential Biomarker for Head and Neck Squamous Cell Carcinoma | |
dc.type | Conference output | |
dc.type.description | E3 - Conferences (Extract Paper) | |
dcterms.bibliographicCitation | Fadhil, R; Wei, M; Nikolarakos, D; Good, D; Nair, R, Mir-3928 in Saliva as Potential Biomarker for Head and Neck Squamous Cell Carcinoma, 2019 | |
dc.date.updated | 2021-02-09T05:32:26Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Wei, Ming Q. | |