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dc.contributor.authorMcCrary, JM
dc.contributor.authorGoldstein, D
dc.contributor.authorSandler, CX
dc.contributor.authorBarry, BK
dc.contributor.authorMarthick, M
dc.contributor.authorTimmins, HC
dc.contributor.authorLi, T
dc.contributor.authorHorvath, L
dc.contributor.authorGrimison, P
dc.contributor.authorPark, SB
dc.date.accessioned2021-02-10T00:56:26Z
dc.date.available2021-02-10T00:56:26Z
dc.date.issued2019
dc.identifier.issn0941-4355
dc.identifier.doi10.1007/s00520-019-04680-w
dc.identifier.urihttp://hdl.handle.net/10072/401924
dc.description.abstractPurpose: Chemotherapy-induced peripheral neuropathy (CIPN) affects up to 40% of cancer survivors and is associated with functional deficits and an increased falls incidence. There are presently no strongly recommended treatment strategies for CIPN. The aim of this study was to evaluate the impact of a multimodal exercise intervention on CIPN symptoms and related functional deficits, as well as neurophysiologic parameters. Methods: All outcomes were assessed before and after an 8-week exercise intervention (3-weekly sessions) and preceding 8-week control period at baseline, pre-exercise and post-exercise. Outcome measures were objective and patient-reported CIPN, standing and dynamic balance, mobility, quality of life, and sensory and motor nerve excitability and conduction studies. Results: Twenty-nine cancer survivors (8 male, 21 female; mean age 61.6 ± 11.8 years) with CIPN symptoms affecting function completed all assessments. Objective and patient-reported CIPN, dynamic balance, standing balance in eyes open conditions, mobility and quality of life were improved from pre- to post-exercise (4.0 < F < 10.2; p <.05), with no changes over the control period (p >.21). No changes were observed in sensory or motor neurophysiologic parameters (p >.23). Conclusions: This study provides encouraging evidence of the rehabilitative potential of multimodal exercise for persisting CIPN in a post-treatment cohort. Large randomised controlled trials are justified to confirm observed benefits and determine the mechanisms and clinical significance.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofpagefrom3849
dc.relation.ispartofpageto3857
dc.relation.ispartofissue10
dc.relation.ispartofjournalSupportive Care in Cancer
dc.relation.ispartofvolume27
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.subject.keywordsAerobic training
dc.subject.keywordsBalance training
dc.subject.keywordsNeurophysiology
dc.subject.keywordsResistance training
dc.subject.keywordsSurvivorship
dc.titleExercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMcCrary, JM; Goldstein, D; Sandler, CX; Barry, BK; Marthick, M; Timmins, HC; Li, T; Horvath, L; Grimison, P; Park, SB, Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy, Supportive Care in Cancer, 2019, 27 (10), pp. 3849-3857
dcterms.dateAccepted2019-01-28
dc.date.updated2021-02-10T00:55:30Z
gro.hasfulltextNo Full Text
gro.griffith.authorSandler, Carolina X.


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