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  • Multifunctional graphene micro-islands: Rapid, low-temperature plasma-enabled synthesis and facile integration for bioengineering genosensing applications

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    Ostrikov218174-Published.pdf (4.380Mb)
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    Accepted Manuscript (AM)
    Author(s)
    Pineda, Shafique
    Borghi, Fabricio Frizera
    Seo, Dong Han
    Yick, Samuel
    Lawn, Malcolm
    van der Laan, Timothy
    Han, Zhao Jun
    Ostrikov, Kostya Ken
    Griffith University Author(s)
    Ostrikov, Ken
    Year published
    2017
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    Abstract
    Here, we present a rapid, low-temperature (200 °C) plasma-enabled synthesis of graphene micro-islands (GMs). Morphological analyses of GMs by scanning electron microscopy (SEM) and atomic force microscopy (AFM) feature a uniform and open-networked array of aggregated graphene sheets. Structural and surface chemical characterizations by Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) support the presence of thin graphitic edges and reactive oxygen functional groups. We demonstrate that these inherent properties of GMs enable its multifunctional capabilities as a bioactive interface. GMs exhibit a biocompatibility ...
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    Here, we present a rapid, low-temperature (200 °C) plasma-enabled synthesis of graphene micro-islands (GMs). Morphological analyses of GMs by scanning electron microscopy (SEM) and atomic force microscopy (AFM) feature a uniform and open-networked array of aggregated graphene sheets. Structural and surface chemical characterizations by Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) support the presence of thin graphitic edges and reactive oxygen functional groups. We demonstrate that these inherent properties of GMs enable its multifunctional capabilities as a bioactive interface. GMs exhibit a biocompatibility of 80% cell viability with primary fibroblast lung cells after 5 days. Further, GMs were assembled into an impedimetric genosensor, and its performance was characterized by electrochemical impedance spectroscopy (EIS). A dynamic sensing range of 1 pM to 1 nM is reported, and a limit of quantification (LOQ) of 2.03×10−13 M is deduced, with selectivity to single-RNA-base mismatched sequences. The versatile nature of GMs may be explored to enable multi-faceted bioactive platforms for next-generation personalized healthcare technologies.
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    Journal Title
    Biosensors and Bioelectronics
    Volume
    89
    Issue
    Pt 1
    DOI
    https://doi.org/10.1016/j.bios.2016.04.072
    Copyright Statement
    © 2017 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Analytical chemistry
    Biomedical engineering
    Nanotechnology
    Science & Technology
    Life Sciences & Biomedicine
    Physical Sciences
    Biophysics
    Biotechnology & Applied Microbiology
    Publication URI
    http://hdl.handle.net/10072/401987
    Collection
    • Journal articles

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