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dc.contributor.authorHerath, HMPD
dc.contributor.authorTaki, AC
dc.contributor.authorSleebs, BE
dc.contributor.authorHofmann, A
dc.contributor.authorNguyen, N
dc.contributor.authorPreston, S
dc.contributor.authorDavis, RA
dc.contributor.authorJabbar, A
dc.contributor.authorGasser, RB
dc.date.accessioned2021-02-12T00:25:10Z
dc.date.available2021-02-12T00:25:10Z
dc.date.issued2021
dc.identifier.isbn9780128246030
dc.identifier.doi10.1016/bs.apar.2020.10.002
dc.identifier.urihttp://hdl.handle.net/10072/402035
dc.description.abstractWidespread resistance to currently-used anthelmintics represents a major obstacle to controlling parasitic nematodes of livestock animals. Given the reliance on anthelmintics in many control regimens, there is a need for the continued discovery and development of new nematocides. Enabling such a focus are: (i) the major chemical diversity of natural products; (ii) the availability of curated, drug-like extract-, fraction- and/or compound-libraries from natural sources; (iii) the utility and practicality of well-established whole-worm bioassays for Haemonchus contortus—an important parasitic nematodes of livestock—to screen natural product libraries; and (iv) the availability of advanced chromatographic (HPLC), spectroscopic (NMR) and spectrometric (MS) techniques for bioassay-guided fractionation and structural elucidation. This context provides a sound basis for the identification and characterisation of anthelmintic candidates from natural sources. This chapter provides a background on the importance and impact of helminth infections/diseases, parasite control and aspects of drug discovery, and reviews recent work focused on (i) screening well-defined compound libraries to establish the methods needed for large-scale screening of natural extract libraries; (ii) discovering plant and marine extracts with nematocidal or nematostatic activity, and purifying bioactive compounds and assessing their potential for further development; and (iii) synthesising analogues of selected purified natural compounds for the identification of possible ‘lead’ candidates. The chapter describes some lessons learned from this work and proposes future areas of focus for drug discovery. Collectively, the findings from this recent work show potential for selected natural product scaffolds as candidates for future development. Developing such candidates via future chemical optimisation, efficacy and safety evaluations, broad spectrum activity assessments, and target identification represents an exciting prospect and, if successful, could pave the way to subsequent pre-clinical and clinical evaluations.
dc.languageeng
dc.publisherElsevier
dc.relation.ispartofbooktitleAdvances in Parasitology
dc.relation.ispartofchapter4
dc.relation.ispartofchapternumbers5
dc.relation.ispartofpagefrom203
dc.relation.ispartofpageto251
dc.relation.ispartofvolume111
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchVeterinary sciences
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3009
dc.subject.fieldofresearchcode3207
dc.subject.keywordsAnthelmintics
dc.subject.keywordsDrug discovery
dc.subject.keywordsDrug resistance
dc.subject.keywordsHaemonchus contortus
dc.subject.keywordsHit and lead identification
dc.titleAdvances in the discovery and development of anthelmintics by harnessing natural product scaffolds
dc.typeBook chapter
dc.type.descriptionB2 - Chapters (Other)
dcterms.bibliographicCitationHerath, HMPD; Taki, AC; Sleebs, BE; Hofmann, A; Nguyen, N; Preston, S; Davis, RA; Jabbar, A; Gasser, RB, Advances in the discovery and development of anthelmintics by harnessing natural product scaffolds, Advances in Parasitology, 2021, 111, pp. 203-251
dc.date.updated2021-02-12T00:21:26Z
gro.hasfulltextNo Full Text
gro.griffith.authorHofmann, Andreas
gro.griffith.authorDavis, Rohan A.


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