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dc.contributor.authorNguyen, Thanh Thi
dc.contributor.authorPathirana, Pubudu N
dc.contributor.authorNguyen, Thin
dc.contributor.authorNguyen, Quoc Viet Hung
dc.contributor.authorBhatti, Asim
dc.contributor.authorNguyen, Dinh C
dc.contributor.authorNguyen, Dung Tien
dc.contributor.authorNguyen, Ngoc Duy
dc.contributor.authorCreighton, Douglas
dc.contributor.authorAbdelrazek, Mohamed
dc.date.accessioned2021-02-12T04:36:19Z
dc.date.available2021-02-12T04:36:19Z
dc.date.issued2021
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/s41598-021-83105-3
dc.identifier.urihttp://hdl.handle.net/10072/402081
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic virus that has caused the global COVID-19 pandemic. Tracing the evolution and transmission of the virus is crucial to respond to and control the pandemic through appropriate intervention strategies. This paper reports and analyses genomic mutations in the coding regions of SARS-CoV-2 and their probable protein secondary structure and solvent accessibility changes, which are predicted using deep learning models. Prediction results suggest that mutation D614G in the virus spike protein, which has attracted much attention from researchers, is unlikely to make changes in protein secondary structure and relative solvent accessibility. Based on 6324 viral genome sequences, we create a spreadsheet dataset of point mutations that can facilitate the investigation of SARS-CoV-2 in many perspectives, especially in tracing the evolution and worldwide spread of the virus. Our analysis results also show that coding genes E, M, ORF6, ORF7a, ORF7b and ORF10 are most stable, potentially suitable to be targeted for vaccine and drug development.
dc.description.peerreviewedYes
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofpagefrom3487
dc.relation.ispartofissue1
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume11
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode0604
dc.titleGenomic mutations and changes in protein secondary structure and solvent accessibility of SARS-CoV-2 (COVID-19 virus)
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNguyen, TT; Pathirana, PN; Nguyen, T; Nguyen, QVH; Bhatti, A; Nguyen, DC; Nguyen, DT; Nguyen, ND; Creighton, D; Abdelrazek, M, Genomic mutations and changes in protein secondary structure and solvent accessibility of SARS-CoV-2 (COVID-19 virus), Scientific Reports, 2021, 11 (1), pp. 3487
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-02-12T03:10:31Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorNguyen, Henry


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