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dc.contributor.authorJessop, Sophie
dc.contributor.authorRuhayel, Sandra
dc.contributor.authorSutton, Rosemary
dc.contributor.authorYoulden, Danny R
dc.contributor.authorPearson, Glenn
dc.contributor.authorLu, Cynthia
dc.contributor.authorMilne, Suzanne
dc.contributor.authorHenderson, Michelle J
dc.contributor.authorAitken, Joanne F
dc.contributor.authorKotecha, Rishi S
dc.contributor.authorRevesz, Tom
dc.date.accessioned2022-03-23T00:18:39Z
dc.date.available2022-03-23T00:18:39Z
dc.date.issued2021
dc.identifier.issn1545-5009
dc.identifier.doi10.1002/pbc.28945
dc.identifier.urihttp://hdl.handle.net/10072/402108
dc.description.abstractBACKGROUND: Presenting features, biology and outcome for childhood leukaemia are known to vary by ethnic origin, geographic location and socioeconomic group. This study aimed to compare presentation patterns, follow-up and clinical outcomes in Indigenous and non-Indigenous children with acute leukaemia in Australia, and to assess the impact of remoteness and area-based socioeconomic disadvantage on outcome. METHODS: A retrospective review of children aged between 1 day and 18 years who were diagnosed with acute leukaemia in South Australia (SA), Northern Territory (NT) and Western Australia (WA) between 2009 and 2018 was performed. Data were collected from children treated at the Women's and Children's Hospital, Adelaide and Perth Children's Hospital. RESULTS: Analysis of 455 children treated for acute leukaemia showed that children from remote/very remote localities had inferior overall survival (p = .004). Five-year overall survival was 91.7% (95% CI: 87.9-94.3%) for children with acute lymphoblastic leukaemia (ALL) and 69.8% (56.7-79.5%) for acute myeloid leukaemia (AML). A larger proportion of Indigenous children from SA/NT were diagnosed with AML compared to non-Indigenous children (60.0% vs. 14.4%, p = .001). Indigenous children were less likely to be enrolled on clinical trials (34.5% vs. 53.1%, p = .03) and more likely to be lost to follow-up (26.1% vs. 9.2%, p = .009). CONCLUSION: Geographic remoteness of residence is associated with inferior overall survival for Australian children with leukaemia. Indigenous children with acute leukaemia suffer from disparities in outcomes. These findings provide evidence to guide national policy in supporting appropriate resource allocation to overcome the challenges faced by children within these groups.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherWiley
dc.relation.ispartofpagefrome28945
dc.relation.ispartofissue4
dc.relation.ispartofjournalPediatric Blood & Cancer
dc.relation.ispartofvolume68
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchReproductive medicine
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3213
dc.subject.fieldofresearchcode3215
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3211
dc.subject.keywordsAustralia
dc.subject.keywordschildhood cancer
dc.subject.keywordsethnicity
dc.subject.keywordsgeographical remoteness
dc.subject.keywordsleukaemia
dc.titleAre outcomes for childhood leukaemia in Australia influenced by geographical remoteness and Indigenous race?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationJessop, S; Ruhayel, S; Sutton, R; Youlden, DR; Pearson, G; Lu, C; Milne, S; Henderson, MJ; Aitken, JF; Kotecha, RS; Revesz, T, Are outcomes for childhood leukaemia in Australia influenced by geographical remoteness and Indigenous race?, Pediatric Blood & Cancer, 2021, 68 (4), pp. e28945
dcterms.dateAccepted2021-01-20
dc.date.updated2021-02-15T00:17:36Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2021 Wiley Periodicals Inc. This is the peer reviewed version of the following article: Are outcomes for childhood leukaemia in Australia influenced by geographical remoteness and Indigenous race?, Pediatric Blood & Cancer, 2021, 68 (4), pp. e28945, which has been published in final form at https://doi.org/10.1002/pbc.28945. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
gro.hasfulltextFull Text
gro.griffith.authorYoulden, Danny R.
gro.griffith.authorAitken, Joanne


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