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dc.contributor.authorXie, Yanfei
dc.contributor.authorThomas, Lucy
dc.contributor.authorBarbero, Macro
dc.contributor.authorFalla, Deborah
dc.contributor.authorJohnston, Venerina
dc.contributor.authorCoombes, Brooke K
dc.date.accessioned2021-03-01T21:40:01Z
dc.date.available2021-03-01T21:40:01Z
dc.date.issued2021
dc.identifier.issn0304-3959
dc.identifier.doi10.1097/j.pain.0000000000002213
dc.identifier.urihttp://hdl.handle.net/10072/402114
dc.description.abstractTo better understand the mechanisms underpinning work-related neck pain, this cross-sectional and single-blinded study compared somatosensory profiles among sonographers with varied neck disability levels. Based on K-mean cluster analysis of scores on the neck disability index (NDI), participants were classified into no (NDI≤8%, n=31, reference group), mild (NDI=10%-20%, n=43) or moderate/severe (NDI≥22%, n=18) disability groups. Data were collected on bodily pain distribution and severity and psychological measures including depression, anxiety, pain-catastrophizing and fear-avoidance beliefs using validated scales. Participants attended one session of quantitative sensory testing performed according to a standardized protocol, including local and remote thermal and mechanical pain thresholds, temporal summation of pain (TSP), conditioned pain modulation (CPM) and an exercise-induced analgesia (EIA) paradigm. Compared to participants with no and mild disability, those with moderate/severe disability showed more widespread pain, cold and mechanical hyperalgesia at a remote non-painful site and significantly higher TSP. Participants with mild disability demonstrated significantly higher TSP than those with no disability. These group differences were attenuated after adjusting for depression or anxiety, indicating these psychological factors may mediate the somatosensory changes associated with neck disability. Group differences were not found for CPM or EIA. These findings suggest that heightened pain facilitation, rather than impaired pain inhibition may underpin nociplastic pain in participants with moderate/severe disability, and it may be associated with depression and anxiety. Clinicians should be aware that individuals with work-related neck pain presenting with moderate/severe disability display distinct somatosensory features and tailor management strategies accordingly.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofjournalPain
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.titleHeightened pain facilitation rather than impaired pain inhibition distinguishes those with moderate/severe disability in work-related neck pain
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationXie, Y; Thomas, L; Barbero, M; Falla, D; Johnston, V; Coombes, BK, Heightened pain facilitation rather than impaired pain inhibition distinguishes those with moderate/severe disability in work-related neck pain., Pain, 2021
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-02-15T00:36:31Z
dc.description.versionSubmitted Manuscript (SM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2021 International Association for the Study of Pain. Published by Elsevier Ltd. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCoombes, Brooke K.


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