dc.contributor.author | Kartasurya, MI | |
dc.contributor.author | Marks, GC | |
dc.contributor.author | Ahmed, F | |
dc.contributor.author | Subagio, HW | |
dc.contributor.author | Rahfiludin, MZ | |
dc.date.accessioned | 2021-02-15T01:19:04Z | |
dc.date.available | 2021-02-15T01:19:04Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1440-6047 | |
dc.identifier.doi | 10.6133/apjcn.202012_29(4).0008 | |
dc.identifier.uri | http://hdl.handle.net/10072/402118 | |
dc.description.abstract | BACKGROUND AND OBJECTIVES: Vitamin A and zinc are interrelated, but the effects of zinc on vitamin A supplementation on morbidity are inconsistent and not well understood. We investigated the effects of zinc and vitamin A supplementation on immune responses in Indonesian pre-schoolers. METHODS AND STUDY DESIGN: In a twostage study design, 826 children (2-5year old) were randomly assigned to receive daily zinc supplement (10 mg) or placebo for 4 months. At 2 months, both groups received a 200,000 IU vitamin A capsules through national vitamin A program. Data were collected at baseline, two and four months, resulting in 4 groups for comparisons: - no zinc no vitamin A (Placebo), zinc only, vitamin A only, and zinc plus vitamin A. Hair, blood and saliva samples were collected to measure hair zinc and serum retinol (vitamin A) concentration, ex-vivo IFN-γ, serum IgG and salivary IgA from 81 children selected randomly from each group. RESULTS: At baseline, there were no differences between treatment groups. Zinc supplementation increased ex-vivo IFN-γ production, greatest amongst boys, younger (<3.5 years), normal weight and children with low baseline retinol concentration. Vitamin A supplementation increased IFN-γ only in those with low baseline retinol, with no effect on serum IgG and salivary IgA. After vitamin A supplementation, zinc had an effect on salivary IgA among younger and underweight children. CONCLUSIONS: Zinc supplementation increased IFN-γ (cellular immune responses) and modified the effect of vitamin A supplementation on salivary IgA (mucosal innate immune response) in younger and underweight children. | |
dc.description.peerreviewed | Yes | |
dc.language | eng | |
dc.relation.ispartofpagefrom | 732 | |
dc.relation.ispartofpageto | 742 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | Asia Pacific journal of clinical nutrition | |
dc.relation.ispartofvolume | 29 | |
dc.subject.fieldofresearch | Nutrition and dietetics | |
dc.subject.fieldofresearchcode | 3210 | |
dc.title | Effect of zinc and vitamin A supplementation on immune responses in Indonesian pre-schoolers | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Kartasurya, MI; Marks, GC; Ahmed, F; Subagio, HW; Rahfiludin, MZ, Effect of zinc and vitamin A supplementation on immune responses in Indonesian pre-schoolers, Asia Pacific journal of clinical nutrition, 2020, 29 (4), pp. 732-742 | |
dc.date.updated | 2021-02-15T01:16:03Z | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © 2020 HEC Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Ahmed, Faruk | |