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dc.contributor.authorCock, IE
dc.contributor.authorGu, B
dc.contributor.authorSirdaarta, J
dc.contributor.authorVan Vuuren, SF
dc.date.accessioned2021-02-17T23:33:16Z
dc.date.available2021-02-17T23:33:16Z
dc.date.issued2017
dc.identifier.issn0254-6299en_US
dc.identifier.doi10.1016/j.sajb.2017.01.038en_US
dc.identifier.urihttp://hdl.handle.net/10072/402300
dc.description.abstractTerminalia sericea Burch. ex. DC (Combretaceae) is used in traditional South African medicine to treat a wide variety of diseases. Several other Terminalia spp. have been reported to have anti-proliferative and apoptotic activities. Despite this, the anticancer properties of T. sericea remain to be rigorously tested. The current study was undertaken to test a panel of T. sericea leaf extracts for the ability to inhibit the proliferation of Caco-2 colorectal and HeLa cervical carcinoma cells, and to identify volatile compounds using GC-MS headspace analysis. Powdered T. sericea leaves were extracted with solvents of varying polarity and investigated for the ability to inhibit the proliferation of Caco-2 and cervical carcinoma cells using MTS based colorimetric cell proliferation assays. The extracts were tested for toxicity in the Artemia nauplii bioassay and the extract with the most potent anti-proliferative activity was examined using headspace GC-MS analysis to identify volatile nonpolar components. The T. sericea leaf extracts displayed potent anti-proliferative activity against Caco-2 and HeLa carcinoma cells. The methanolic extracts were particularly potent inhibitors of Caco-2 and HeLa proliferation. The aqueous and ethyl acetate extracts (but not the chloroform or hexane extracts) also significantly inhibited carcinoma proliferation, albeit with substantially lower potency. Subsequent analysis of the T. sericea leaf extracts by GC-MS headspace analysis highlighted several interesting volatile compounds. All extracts were shown to be non-toxic in the Artemia nauplii bioassay. The lack of toxicity of these extracts and their anti-proliferative bioactivity against Caco-2 and HeLa carcinoma cells indicates their potential in the treatment of some cancers.en_US
dc.languageEnglishen_US
dc.publisherElsevieren_US
dc.relation.ispartofconferencetitleSouth African Journal of Botanyen_US
dc.relation.ispartofpagefrom329en_US
dc.relation.ispartofpageto330en_US
dc.relation.ispartofvolume109en_US
dc.subject.fieldofresearchEcologyen_US
dc.subject.fieldofresearchPlant Biologyen_US
dc.subject.fieldofresearchcode0602en_US
dc.subject.fieldofresearchcode0607en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsPlant Sciencesen_US
dc.titleInhibition of Caco-2 and HeLa proliferation by Terminalia sericea Burch. ex DC. (Combretaceae) leaf extracts and identification of volatile componentsen_US
dc.typeConference outputen_US
dc.type.descriptionE3 - Conferences (Extract Paper)en_US
dcterms.bibliographicCitationCock, IE; Gu, B; Sirdaarta, J; Van Vuuren, SF, Inhibition of Caco-2 and HeLa proliferation by Terminalia sericea Burch. ex DC. (Combretaceae) leaf extracts and identification of volatile components, South African Journal of Botany, 2017, 109, pp. 329-330en_US
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-02-17T23:27:33Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© The Author(s) 2017. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.


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