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dc.contributor.authorSingh, K
dc.contributor.authorSubhaharan, D
dc.contributor.authorMridha, N
dc.description.abstractBackground: Progress in the platforms for DES is aimed at improving safety and outcomes. Second-generation DESs have a biocompatible durable polymer (DP), in addition to bioabsorbable polymers (BP). The benefit of BP is to remove the polymer-triggered inflammatory stimulation associated with DP. There is evidence to suggest BP-DESs are non-inferior to the current generation DES at 12 months. The time course for polymer absorption varies between stents and may take from 4 to 15 months. Hence the potential benefits of BP-DES over DP-DES can only be tested over a longer period, to overcome the time taken for polymer absorption. Purpose: The purpose of the meta-analysis was to compare the safety and efficacy outcomes of BP-DES over a long-term follow-up. Methods: A thorough computer-based search using Ovid MEDLINE, EMBASE, Google Scholar, and PubMed databases was conducted up to 11 November 2017. We only included randomised studies (RCT) comparing clinical outcomes between the BP-DESs and DP-DESs. Only studies where data were available for a minimum of 5 years were included. Safety (Stent thrombosis (ST) and reinfarction) and efficacy (target lesion revascularization (TLR), cardiac mortality) were analysed. Results: The literature search yielded 445 citations. After going through the abstracts and full-texts of the articles we included 5 RCTs where 5-year follow-up data was available. The information about the included studies, stent platform, drug and type of polymer is provided in Table 1.There was no difference in the ST (OR 0.71, 95% CI 0.47 –1.09, I2 = 31%, P=0.12), reinfarction (OR 1.01, 95% CI 0.85 –1.21, I2 = 0%, P=0.89), cardiac mortality (OR 1.00, 95% CI 0.81 –1.23, I2 = 0%, P=0.98), all cause mortality (OR 0.95, 95% CI 0.80 –1.14, I2 = 21%, P=0.61) and TLR (OR 0.80, 95% CI 0.58–1.11, I2 = 68%, P=0.18). Furthermore, there was no difference in the very late ST (OR 0.49, 95% CI 0.19 –1.30, I2 = 56%, P=0.15).
dc.publisherOxford University Press
dc.relation.ispartofconferencenameEuropean-Society-of-Cardiology Congress
dc.relation.ispartofconferencetitleEuropean Heart Journal
dc.relation.ispartoflocationMunich, Germany
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchClinical sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCardiac & Cardiovascular Systems
dc.subject.keywordsCardiovascular System & Cardiology
dc.titleA five-year follow-up of randomised studies comparing outcomes between bioabsorbable-polymer and durable-polymer drug-eluting stents: systematic review and meta-analysis
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dcterms.bibliographicCitationSingh, K; Subhaharan, D; Mridha, N, A five-year follow-up of randomised studies comparing outcomes between bioabsorbable-polymer and durable-polymer drug-eluting stents: systematic review and meta-analysis, European Heart Journal, 2018, 39, pp. 1149-1149
gro.hasfulltextNo Full Text
gro.griffith.authorSubhaharan, Deloshaan
gro.griffith.authorMridha, Naim
gro.griffith.authorSingh, Kuljit

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