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dc.contributor.authorSandoval-Acuna, Cristian
dc.contributor.authorTomkova, Veronika
dc.contributor.authorCardenas, Natalia Torrealba
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorRepkova, Krystina
dc.contributor.authorStursa, Jan
dc.contributor.authorWerner, Lukas
dc.contributor.authorTruksa, Jaroslav
dc.date.accessioned2021-02-19T01:43:26Z
dc.date.available2021-02-19T01:43:26Z
dc.date.issued2018
dc.identifier.issn0891-5849
dc.identifier.doi10.1016/j.freeradbiomed.2018.04.202
dc.identifier.urihttp://hdl.handle.net/10072/402388
dc.description.abstractIron is an indispensable micronutrient required for function of key cellular enzymes required for DNA replication and repair, and for mitochondrial respiration and metabolism. Within cells, iron is primarily utilized in mitochondria, where it is essential for the synthesis of Fe-S clusters and heme. The role of iron in carcinogenesis is widely accepted, and tumor cells require higher amounts of iron for their survival and proliferation. Indeed, iron chelation has been proposed as an alternative strategy to target cancer cells. Therefore, we synthesized a mitochondrially targeted derivative of the iron chelator deferoxamine (mDFO) and evaluated its ability to eliminate cancer cells selectively. Our results show that mDFO is at least 100-fold more efficient than DFO in killing breast cancer cells. Moreover, mDFO was able to reduce mitochondrial respiration and aconitase activity, increase mitochondrial and cellular ROS production, and trigger the activation of mitophagy. Taken together, our data strongly support the role of mDFO as a novel and efficient compound in the selective elimination of cancer cells.
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofconferencename19th biennial meeting for the Society for Free Radical Research International (SFRRI)
dc.relation.ispartofconferencetitleFree Radical Biology and Medicine
dc.relation.ispartofdatefrom2018-06-04
dc.relation.ispartofdateto2018-06-07
dc.relation.ispartoflocationLisbon, Portugal
dc.relation.ispartofpagefromS61
dc.relation.ispartofpagetoS61
dc.relation.ispartofvolume120
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical biochemistry and metabolomics
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3205
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsEndocrinology & Metabolism
dc.subject.keywordsMolecular Biology
dc.titleMitochondrial iron chelation as a novel anti-cancer strategy
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dcterms.bibliographicCitationSandoval-Acuna, C; Tomkova, V; Cardenas, NT; Neuzil, J; Repkova, K; Stursa, J; Werner, L; Truksa, J, Mitochondrial iron chelation as a novel anti-cancer strategy, Free Radical Biology and Medicine, 2018, 120, pp. S61-S61
dc.date.updated2021-02-19T01:34:03Z
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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