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dc.contributor.authorKillen, BA
dc.contributor.authorFalisse, A
dc.contributor.authorDe Groote, F
dc.contributor.authorJonkers, I
dc.date.accessioned2021-02-19T02:30:08Z
dc.date.available2021-02-19T02:30:08Z
dc.date.issued2020
dc.identifier.issn2076-3417
dc.identifier.doi10.3390/app10207255
dc.identifier.urihttp://hdl.handle.net/10072/402396
dc.description.abstractOver the past decades, the use of computational physics-based models representative of the musculoskeletal (MSK) system has become increasingly popular in many fields of clinically driven research, locomotor rehabilitation in particular. These models have been applied to various functional impairments given their ability to estimate parameters which cannot be readily measured in vivo but are of interest to clinicians. The use of MSK modelling and simulations allows analysis of relevant MSK biomarkers such as muscle and joint contact loading at a number of different stages in the clinical treatment pathway in order to benefit patient functional outcome. Applications of these methods include optimisation of rehabilitation programs, patient stratification, disease characterisation, surgical pre-planning, and assistive device and exoskeleton design and optimisation. This review provides an overview of current approaches, the components of standard MSK models, applications, limitations, and assumptions of these modelling and simulation methods, and finally proposes a future direction.
dc.description.peerreviewedYes
dc.languageen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto22
dc.relation.ispartofissue20
dc.relation.ispartofjournalApplied Sciences
dc.relation.ispartofvolume10
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.titleIn silico-enhanced treatment and rehabilitation planning for patients with musculoskeletal disorders: Can musculoskeletal modelling and dynamic simulations really impact current clinical practice?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKillen, BA; Falisse, A; De Groote, F; Jonkers, I, In silico-enhanced treatment and rehabilitation planning for patients with musculoskeletal disorders: Can musculoskeletal modelling and dynamic simulations really impact current clinical practice?, Applied Sciences, 2020, 10 (20), pp. 1-22
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-02-18T23:47:10Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s), 2020. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorKillen, Bryce A.


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