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  • Rapid translation of COVID-19 preprint data into critical care practice

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    Richards462109Published.pdf (624.9Kb)
    Author(s)
    Burrell, AJC
    Neto, AS
    Trapani, T
    Broadley, T
    French, C
    Udy, AA
    Visser, A
    Mattke, A
    Regli, A
    Rashid, A
    Tabah, A
    Richards, B
    White, H
    Lister, P
    et al.
    Griffith University Author(s)
    Richards, Brent V.
    White, Hayden T.
    Lister, Paula
    Year published
    2021
    Metadata
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    Abstract
    To the Editor: The global coronavirus disease (COVID-19) pandemic has seen a significant increase in the use of preprint services to enable the widespread dissemination of research findings (1). However, whether such facilities influence practice change is currently unknown. Here, we describe the impact of the preprint release and eventual publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (2) on corticosteroid use in clinical practice in Australian ICUs. The RECOVERY trial tested the efficacy of dexamethasone (6 mg by mouth or intravenously for up to 10 d) in hospitalized patients with clinically ...
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    To the Editor: The global coronavirus disease (COVID-19) pandemic has seen a significant increase in the use of preprint services to enable the widespread dissemination of research findings (1). However, whether such facilities influence practice change is currently unknown. Here, we describe the impact of the preprint release and eventual publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (2) on corticosteroid use in clinical practice in Australian ICUs. The RECOVERY trial tested the efficacy of dexamethasone (6 mg by mouth or intravenously for up to 10 d) in hospitalized patients with clinically suspected or confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and demonstrated a reduction in 28-day mortality, particularly in those receiving either mechanical ventilation or oxygen. Before these results, the Australian and New Zealand Intensive Care Society COVID-19 guidelines recommended against the routine use of corticosteroids (3).
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    Journal Title
    American Journal of Respiratory and Critical Care Medicine
    Volume
    203
    Issue
    3
    DOI
    https://doi.org/10.1164/rccm.202009-3661LE
    Copyright Statement
    © The Author(s) 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/402452
    Collection
    • Journal articles

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