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dc.contributor.authorHussain, Iqra
dc.contributor.authorTasneem, Fareeda
dc.contributor.authorGilani, Usman Shah
dc.contributor.authorArshad, Muhammad Imran
dc.contributor.authorul Hague, Muhammad Farhan
dc.contributor.authorAbbas, Zaigham
dc.contributor.authorUmer, Muhammed
dc.contributor.authorShahzad, Naveed
dc.description.abstractPolyomaviridae family consists of small circular dsDNA viruses. Out of the 14 human polyomaviruses described so far, BKPyV and JCPyV have been studied extensively since their discovery in 1971. Reportedly, both BKPyV and JCPyV are widely distributed across the globe with the frequency of 80–90 % in different populations. The primary infection of these viruses is usually asymptomatic and latent which is activated as a consequence of immunosuppression. Activated BKPyV and JCPyV viruses lead to the development of BK Virus Associated Nephropathy and Progressive Multifocal Leukoencephalopathy, respectively. Immense progress has been made during the last few decades regarding the molecular understanding of polyomaviruses. Epidemiology of polyomaviruses has also been studied extensively. However, most of the epidemiological studies have focused on European and American populations. Therefore, limited data is available regarding the geographical distribution of these potentially oncogenic viruses in Asian countries. In this article, we have presented a compendium of latest advances in the molecular understanding of polyomaviruses and their pathobiology. We also present a comprehensive review of published literature regarding the epidemiology and prevalence of BKPyV and JCPyV in Asian regions. For this purpose, a thorough search of available online resources was performed. As a result, we retrieved 24 studies for BKPyV and 22 studies for JCPyV, that describe their prevalence in Asia. These studies unanimously report high occurrence of both BKPyV and JCPyV in Asian populations. The available data from these studies was categorized into two groups: on the basis of prevalence (low, medium and high) and disease development (healthy and diseased). Altogether, Korean population hasbeen evidenced to possess highest frequency of BKPyV (66.7 %), while JCPyV was found to be most prevalent in Taiwan (88 %). Due to high and ubiquitous distribution of these viruses, frequent studies are required to develop a better understanding regarding the epidemiology and pathobiology of these viruses in Asia.en_US
dc.relation.ispartofjournalVirus Researchen_US
dc.subject.fieldofresearchBiological Sciencesen_US
dc.subject.fieldofresearchAgricultural and Veterinary Sciencesen_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsBK polyomavirusen_US
dc.subject.keywordsJC polyomavirusen_US
dc.titleHuman BK and JC polyomaviruses: Molecular insights and prevalence in Asiaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationHussain, I; Tasneem, F; Gilani, US; Arshad, MI; ul Hague, MF; Abbas, Z; Umer, M; Shahzad, N, Human BK and JC polyomaviruses: Molecular insights and prevalence in Asia, Virus Research, 2020, 278, pp. 197860en_US
gro.hasfulltextNo Full Text
gro.griffith.authorUmer, Muhammad

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