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dc.contributor.authorVarney, Rebecca M
dc.contributor.authorSpeiser, Daniel I
dc.contributor.authorMcDougall, Carmel
dc.contributor.authorDegnan, Bernard M
dc.contributor.authorKocot, Kevin M
dc.date.accessioned2021-02-24T03:03:41Z
dc.date.available2021-02-24T03:03:41Z
dc.date.issued2021
dc.identifier.issn1759-6653
dc.identifier.doi10.1093/gbe/evaa263
dc.identifier.urihttp://hdl.handle.net/10072/402546
dc.description.abstractMolluscs biomineralize structures that vary in composition, form, and function, prompting questions about the genetic mechanisms responsible for their production and the evolution of these mechanisms. Chitons (Mollusca, Polyplacophora) are a promising system for studies of biomineralization because they build a range of calcified structures including shell plates and spine- or scale-like sclerites. Chitons also harden the calcified teeth of their rasp-like radula with a coat of iron (as magnetite). Here we present the genome of the West Indian fuzzy chiton Acanthopleura granulata, the first from any aculiferan mollusc. The A. granulata genome contains homologs of many genes associated with biomineralization in conchiferan molluscs. We expected chitons to lack genes previously identified from pathways conchiferans use to make biominerals like calcite and nacre because chitons do not use these materials in their shells. Surprisingly, the A. granulata genome has homologs of many of these genes, suggesting that the ancestral mollusc may have had a more diverse biomineralization toolkit than expected. The A. granulata genome has features that may be specialized for iron biomineralization, including a higher proportion of genes regulated directly by iron than other molluscs. A. granulata also produces two isoforms of soma-like ferritin: one is regulated by iron and similar in sequence to the soma-like ferritins of other molluscs, and the other is constitutively translated and is not found in other molluscs. The A. granulata genome is a resource for future studies of molluscan evolution and biomineralization.
dc.description.peerreviewedYes
dc.languageen
dc.publisherOxford University Press (OUP)
dc.relation.ispartofissue1
dc.relation.ispartofjournalGenome Biology and Evolution
dc.relation.ispartofvolume13
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchEvolutionary Biology
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0603
dc.subject.fieldofresearchcode0604
dc.titleThe Iron-Responsive Genome of the Chiton Acanthopleura granulata
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationVarney, RM; Speiser, DI; McDougall, C; Degnan, BM; Kocot, KM, The Iron-Responsive Genome of the Chiton Acanthopleura granulata, Genome Biology and Evolution, 2021, 13 (1)
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-02-24T01:28:44Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorMcDougall, Carmel


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