Show simple item record

dc.contributor.authorGalvão, DA
dc.contributor.authorNewton, RU
dc.contributor.authorChambers, SK
dc.contributor.authorSpry, N
dc.contributor.authorJoseph, D
dc.contributor.authorGardiner, RA
dc.contributor.authorFairman, CM
dc.contributor.authorTaaffe, DR
dc.date.accessioned2021-03-01T00:46:07Z
dc.date.available2021-03-01T00:46:07Z
dc.date.issued2021
dc.identifier.issn1365-7852en_US
dc.identifier.doi10.1038/s41391-021-00327-2en_US
dc.identifier.urihttp://hdl.handle.net/10072/402679
dc.description.abstractObjectives: To assess the long-term effects of various exercise modes on psychological distress in men with prostate cancer on androgen deprivation therapy (ADT). Patients and methods: 135 prostate cancer patients aged 43–90 years on ADT were randomized to twice weekly supervised impact loading and resistance exercise (ImpRes), supervised aerobic and resistance exercise (AerRes), and usual care/delayed supervised aerobic exercise (DelAer) for 12 months, and completed measures of psychological distress using the Brief Symptom Inventory-18 (BSI-18). BSI-18 provides three subscales for anxiety, depression, and somatisation, as well as the global severity index (GSI) where higher scores indicate higher distress. Results: Following the intervention, somatization was not different to baseline, however, there were significant interactions (p < 0.01) for depression, anxiety, and the GSI. In ImpRes, depression was reduced at 12 months compared to baseline and 6 months (0.78 ± 1.39 vs. 1.88 ± 3.24 and 1.48 ± 2.65, p < 0.001), as was the GSI (3.67 ± 4.34 vs. 5.94 ± 7.46 and 4.64 ± 4.73, p < 0.001) with anxiety reduced compared to baseline (1.08 ± 1.54 vs. 1.98 ± 2.56). Depression and the GSI decreased (p < 0.05) in AerRes at 6 months but increased by 12 months, while in DelAer the GSI was reduced at 12 months compared to 6 months (3.78 ± 3.94 vs. 5.25 ± 4.22, p = 0.031). Men with the highest level of anxiety, depression, somatization, and the GSI improved the most with exercise (ptrend < 0.001). Conclusion: Various supervised exercise modes (aerobic, resistance and impact loading) are effective in reducing psychological distress in men with prostate cancer on ADT. Those with the highest level of psychological distress improved the most. Supervised exercise should be prescribed to improve psychological health in prostate cancer patients on ADT.en_US
dc.description.peerreviewedYesen_US
dc.languageenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofjournalProstate Cancer and Prostatic Diseasesen_US
dc.subject.fieldofresearchOncology and Carcinogenesisen_US
dc.subject.fieldofresearchcode1112en_US
dc.titlePsychological distress in men with prostate cancer undertaking androgen deprivation therapy: modifying effects of exercise from a year-long randomized controlled trialen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationGalvão, DA; Newton, RU; Chambers, SK; Spry, N; Joseph, D; Gardiner, RA; Fairman, CM; Taaffe, DR, Psychological distress in men with prostate cancer undertaking androgen deprivation therapy: modifying effects of exercise from a year-long randomized controlled trial, Prostate Cancer and Prostatic Diseases, 2021en_US
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-02-28T23:12:26Z
dc.description.versionVersion of Record (VoR)en_US
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.en_US
gro.rights.copyright© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_US
gro.hasfulltextFull Text
gro.griffith.authorChambers, Suzanne K.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record