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  • Cytokines and splenic remodelling during Leishmania donovani infection.

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    Engwerda463025-Published.pdf (2.463Mb)
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    Version of Record (VoR)
    Author(s)
    Montes de Oca, Marcela
    Engwerda, Christian R
    Kaye, Paul M
    Griffith University Author(s)
    Engwerda, Christian R.
    Year published
    2020
    Metadata
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    Abstract
    Visceral leishmaniasis (VL) causes extensive splenic pathology that contributes to dysfunctional immune responses, in part through displacement and destruction of cell populations involved in maintaining splenic structural integrity. The expression of pro and anti-inflammatory cytokines and chemokines is crucial in orchestrating the delicate balance that exists between host resistance and tissue pathology. In an effort to restore homeostatic balance to the local microenvironment, remodelling of the splenic architecture occurs in a compartmentalised manner to retain some level of functionality, despite persistent inflammatory ...
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    Visceral leishmaniasis (VL) causes extensive splenic pathology that contributes to dysfunctional immune responses, in part through displacement and destruction of cell populations involved in maintaining splenic structural integrity. The expression of pro and anti-inflammatory cytokines and chemokines is crucial in orchestrating the delicate balance that exists between host resistance and tissue pathology. In an effort to restore homeostatic balance to the local microenvironment, remodelling of the splenic architecture occurs in a compartmentalised manner to retain some level of functionality, despite persistent inflammatory pressures. Animal models of VL as well as human studies have significantly contributed to our understanding of the architectural changes that occur in the spleen during VL. Here, we review the role of cytokines in mediating microarchitectural changes associated with the development of splenomegaly during VL.
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    Journal Title
    Cytokine X
    Volume
    2
    Issue
    4
    DOI
    https://doi.org/10.1016/j.cytox.2020.100036
    Copyright Statement
    © 2020 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Clinical Sciences
    Cytokines
    Follicles
    Inflammation
    PALS
    Pathology
    Publication URI
    http://hdl.handle.net/10072/402700
    Collection
    • Journal articles

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