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dc.contributor.authorMontes de Oca, Marcela
dc.contributor.authorEngwerda, Christian R
dc.contributor.authorKaye, Paul M
dc.date.accessioned2021-03-01T05:02:50Z
dc.date.available2021-03-01T05:02:50Z
dc.date.issued2020
dc.identifier.issn2590-1532
dc.identifier.doi10.1016/j.cytox.2020.100036
dc.identifier.urihttp://hdl.handle.net/10072/402700
dc.description.abstractVisceral leishmaniasis (VL) causes extensive splenic pathology that contributes to dysfunctional immune responses, in part through displacement and destruction of cell populations involved in maintaining splenic structural integrity. The expression of pro and anti-inflammatory cytokines and chemokines is crucial in orchestrating the delicate balance that exists between host resistance and tissue pathology. In an effort to restore homeostatic balance to the local microenvironment, remodelling of the splenic architecture occurs in a compartmentalised manner to retain some level of functionality, despite persistent inflammatory pressures. Animal models of VL as well as human studies have significantly contributed to our understanding of the architectural changes that occur in the spleen during VL. Here, we review the role of cytokines in mediating microarchitectural changes associated with the development of splenomegaly during VL.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofpagefrom100036
dc.relation.ispartofissue4
dc.relation.ispartofjournalCytokine X
dc.relation.ispartofvolume2
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsCytokines
dc.subject.keywordsFollicles
dc.subject.keywordsInflammation
dc.subject.keywordsPALS
dc.subject.keywordsPathology
dc.titleCytokines and splenic remodelling during Leishmania donovani infection.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMontes de Oca, M; Engwerda, CR; Kaye, PM, Cytokines and splenic remodelling during Leishmania donovani infection., Cytokine X, 2020, 2 (4), pp. 100036-
dcterms.dateAccepted2020-08-24
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-03-01T04:42:53Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorEngwerda, Christian R.


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