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dc.contributor.authorWalsh, Stephen
dc.contributor.authorCorbett, Joel
dc.contributor.authorTan, K Meng
dc.contributor.authorBroadley, Simon
dc.description.abstractIntroduction Epileptic seizures have been described in association with multiple sclerosis (MS) in both anecdotal case reports and case series. The recent identification of specific antibodies to myelin oligodendrocyte glycoprotein (MOG) protein in a small number of patients with demyelinating disease which may resemble neuromyelitis optica or acute disseminated encephalopathy, which may involve seizures, raises the possibility that anti-MOG antibody related demyelination may account for the association of epilepsy with MS. Methods We have undertaken a retrospective review of cases of MS diagnosed at the Gold Coast MS clinic over a 10 year period. All cases were systematically asked if they had ever had an epileptic seizure either via a patient completed questionnaire or at a clinic visit. Demographic and clinical information were also recorded. These data have been analysed using descriptive statistics and appropriate tests for significant differences between those with epilepsy and those without. Results 428 cases with complete data were identified. Those with a history of epilepsy were slightly younger (median (range); 44.5 (27–64) years vs 4715–88 years), but this difference was not statistically significantly different. The gender ratio was the same for both groups (9/12 (75%) for those with epilepsy and 326/416 (78%)). There was no significant difference in age of onset, disease course, relapse frequency or level of disability. Although numbers are small, seizure appear to occur most frequently earlier in the disease course and are rarely an ongoing issue. Conclusion These data support earlier work indicating that epilepsy occurs in people with MS who are younger. This fits with the notion that seizures arise in the context of the inflammatory stage of multiple sclerosis rather than the degenerative phase. Further work needs to be undertaken to assess any association with anti-MOG antibodies and epileptic seizures in demyelinating disease.en_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofconferencenameAnnual Scientific Meeting of the Australian-and-New Zealand-Association-of-Neurologists (ANZAN)en_US
dc.relation.ispartofconferencetitleJournal of Neurology Neurosurgery and Psychiatryen_US
dc.relation.ispartoflocationDarwin, Australiaen_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.fieldofresearchPsychology and Cognitive Sciencesen_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsClinical Neurologyen_US
dc.titleEpileptic seizures in multiple sclerosisen_US
dc.typeConference outputen_US
dc.type.descriptionE3 - Conferences (Extract Paper)en_US
dcterms.bibliographicCitationWalsh, S; Corbett, J; Tan, KM; Broadley, S, Epileptic seizures in multiple sclerosis, Journal of Neurology Neurosurgery and Psychiatry, 2018, 89 (6), pp. E44-E44en_US
gro.hasfulltextNo Full Text
gro.griffith.authorBroadley, Simon

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    Contains papers delivered by Griffith authors at national and international conferences.

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