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dc.contributor.authorKhatun, Farjana
dc.contributor.authorDai, Charles C
dc.contributor.authorRivera-Hernandez, Tania
dc.contributor.authorHussein, Waleed M
dc.contributor.authorKhalil, Zeinab G
dc.contributor.authorCapon, Robert J
dc.contributor.authorToth, Istvan
dc.contributor.authorStephenson, Rachel J
dc.description.abstractIdentifying the immunogenic moieties and their precise structure of carbohydrates plays an important role for developing effective carbohydrate-based subunit vaccines. This study assessed the structure–immunogenicity relationship of carbohydrate moieties of a single repeating unit of group A carbohydrate (GAC) present on the cell wall of group A Streptococcus (GAS) using a rationally designed self-adjuvanted lipid-core peptide, instead of a carrier protein. Immunological evaluation of fully synthetic glyco-lipopeptides (particle size: 300–500 nm) revealed that construct consisting of higher rhamnose moieties (trirhamnosyl-lipopeptide) was able to induce enhanced immunogenic activity in mice, and GlcNAc moiety was not found to be an essential component of immunogenic GAC mimicked epitope. Trirhamnosyl-lipopeptide also showed 75–97% opsonic activity against four different clinical isolates of GAS and was comparable to a subunit peptide vaccine (J8-lipopeptide) which illustrated 65–96% opsonic activity.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofjournalACS Infectious Diseases
dc.subject.fieldofresearchMedical Microbiology
dc.titleImmunogenicity Assessment of Cell Wall Carbohydrates of Group A Streptococcus via Self-Adjuvanted Glyco-lipopeptides
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKhatun, F; Dai, CC; Rivera-Hernandez, T; Hussein, WM; Khalil, ZG; Capon, RJ; Toth, I; Stephenson, RJ, Immunogenicity Assessment of Cell Wall Carbohydrates of Group A Streptococcus via Self-Adjuvanted Glyco-lipopeptides, ACS Infectious Diseases, 2021, 7 (2), pp. 390-405
gro.hasfulltextNo Full Text
gro.griffith.authorDai, Charles C.

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