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dc.contributor.authorKi, KK
dc.contributor.authorMillar, JE
dc.contributor.authorLangguth, D
dc.contributor.authorPassmore, MR
dc.contributor.authorMcDonald, CI
dc.contributor.authorShekar, K
dc.contributor.authorShankar-Hari, M
dc.contributor.authorCho, HJ
dc.contributor.authorSuen, JY
dc.contributor.authorFraser, JF
dc.date.accessioned2021-03-11T03:04:59Z
dc.date.available2021-03-11T03:04:59Z
dc.date.issued2021
dc.identifier.issn1664-3224
dc.identifier.doi10.3389/fimmu.2020.600684
dc.identifier.urihttp://hdl.handle.net/10072/403062
dc.description.abstractA plethora of leukocyte modulations have been reported in critically ill patients. Critical illnesses such as acute respiratory distress syndrome and cardiogenic shock, which potentially require extracorporeal membrane oxygenation (ECMO) support, are associated with changes in leukocyte numbers, phenotype, and functions. The changes observed in these illnesses could be compounded by exposure of blood to the non-endothelialized surfaces and non-physiological conditions of ECMO. This can result in further leukocyte activation, increased platelet-leukocyte interplay, pro-inflammatory and pro-coagulant state, alongside features of immunosuppression. However, the effects of ECMO on leukocytes, in particular their phenotypic and functional signatures, remain largely overlooked, including whether these changes have attributable mortality and morbidity. The aim of our narrative review is to highlight the importance of studying leukocyte signatures to better understand the development of complications associated with ECMO. Increased knowledge and appreciation of their probable role in ECMO-related adverse events may assist in guiding the design and establishment of targeted preventative actions.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherFrontiers Media SA
dc.relation.ispartofpagefrom600684
dc.relation.ispartofjournalFrontiers in Immunology
dc.relation.ispartofvolume11
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3204
dc.subject.fieldofresearchcode3207
dc.subject.keywordscritically ill patients
dc.subject.keywordsextracorporeal membrane oxygenation
dc.subject.keywordsextracorporeal membrane oxygenation technology
dc.subject.keywordsinnate and adaptive immunity
dc.subject.keywordsleukocyte modulation
dc.titleCurrent Understanding of Leukocyte Phenotypic and Functional Modulation During Extracorporeal Membrane Oxygenation: A Narrative Review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKi, KK; Millar, JE; Langguth, D; Passmore, MR; McDonald, CI; Shekar, K; Shankar-Hari, M; Cho, HJ; Suen, JY; Fraser, JF, Current Understanding of Leukocyte Phenotypic and Functional Modulation During Extracorporeal Membrane Oxygenation: A Narrative Review, Frontiers in Immunology, 2021, 11, pp. 600684
dcterms.dateAccepted2020-11-23
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-03-11T01:40:15Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 Ki, Millar, Langguth, Passmore, McDonald, Shekar, Shankar-Hari, Cho, Suen and Fraser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorFraser, John F.


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