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dc.contributor.authorMustapić, M
dc.contributor.authorGlumac, Z
dc.contributor.authorHeffer, M
dc.contributor.authorZjalić, M
dc.contributor.authorProloščić, I
dc.contributor.authorMasud, M
dc.contributor.authorBlažetić, S
dc.contributor.authorVuković, A
dc.contributor.authorBillah, M
dc.contributor.authorKhan, A
dc.contributor.authorŠegota, S
dc.contributor.authorAl Hossain, MS
dc.date.accessioned2021-03-15T04:02:16Z
dc.date.available2021-03-15T04:02:16Z
dc.date.issued2021
dc.identifier.issn0304-3894
dc.identifier.doi10.1016/j.jhazmat.2020.124918
dc.identifier.urihttp://hdl.handle.net/10072/403156
dc.description.abstractContinuing our previous research work on a drug delivery system based on combined AC/DC magnetic fields, we have developed a prototype AC/DC magnetic syringe device for stimulation of drug release from drug carriers, with the options of injecting/removing drug carriers. The porous Fe3O4 carrier, in a dose-dependent manner, causes acute oxidative damage and reduces the viability of differentiated SH-SY5Y human neuroblastoma cells, indicating the necessity for its removal once it reaches the therapeutic concentration at the target tissue. The working mechanism of the device consists of three simple steps. First, direct injection of the drug adsorbed on the surface of a carrier via a needle inserted into the targeted area. The second step is stimulation of drug release using a combination of AC magnetic field (a coil magnetised needle with AC current) and permanent magnets (DC magnetic lens outside of the body), and the third step is removal of the drug carriers from the injected area after the completion of drug release by magnetising the tip of the needle with DC current. Removing the drug carriers allows us to avoid possible acute and long term side effects of the drug carriers in the patient's body, as well as any potential response of the body to the drug carriers.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofpagefrom124918
dc.relation.ispartofjournalJournal of Hazardous Materials
dc.relation.ispartofvolume409
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchEnvironmental sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode41
dc.subject.fieldofresearchcode40
dc.subject.keywordsCytotoxicity
dc.subject.keywordsEnzyme activity
dc.subject.keywordsMagnetic nanoparticles
dc.subject.keywordsOxidative stress
dc.titleAC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMustapić, M; Glumac, Z; Heffer, M; Zjalić, M; Prološčić, I; Masud, M; Blažetić, S; Vuković, A; Billah, M; Khan, A; Šegota, S; Al Hossain, MS, AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers, Journal of Hazardous Materials, 2021, 409, pp. 124918
dcterms.dateAccepted2020-10-31
dc.date.updated2021-03-15T00:37:28Z
gro.hasfulltextNo Full Text
gro.griffith.authorMasud, Mostafa Kamal K.


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