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  • Ageing Alters Right Ventricular But Not Left Ventricular Myocardial Mechanics

    Author(s)
    Stewart, Glenn
    Johnson, Bruce
    Balmain, Bryce
    Shino, Kenji
    Yamada, Akira
    Morris, Norman
    Chan, Jonathan
    Sabapathy, Surendran
    Griffith University Author(s)
    Sabapathy, Surendran
    Yamada, Akira
    Chan, Jonathan H.
    Balmain, Bryce N.
    Morris, Norman
    Year published
    2018
    Metadata
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    Abstract
    Introduction: Ageing is associated with a progressive stiffening of the pulmonary vasculature that causes an increase in pulmonary vascular resistance and a decrease in compliance. It remains unclear if right ventricular myocardial mechanics adapt in response to age-related remodeling in the pulmonary vasculature. PURPOSE: Accordingly, this study examined global and transmural longitudinal myocardial tissue deformation (strain) in a cohort of healthy young and middle-aged men to characterize age-related changes in myocardial tissue mechanics. METHODS: Two-dimensional echocardiography was used to measure left (LV) and right ...
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    Introduction: Ageing is associated with a progressive stiffening of the pulmonary vasculature that causes an increase in pulmonary vascular resistance and a decrease in compliance. It remains unclear if right ventricular myocardial mechanics adapt in response to age-related remodeling in the pulmonary vasculature. PURPOSE: Accordingly, this study examined global and transmural longitudinal myocardial tissue deformation (strain) in a cohort of healthy young and middle-aged men to characterize age-related changes in myocardial tissue mechanics. METHODS: Two-dimensional echocardiography was used to measure left (LV) and right (RV) ventricular strain in 10 young men (YM; Age: 27 ± 2yr, BMI: 23.2 ± 2.4m2) and 10 middle aged men (MAM; Age: 61 ± 7yr, BMI: 25.9 ± 3.2m2). A transmural strain gradient was calculated as the difference between endocardial and epicardial strain as an index of regional non-uniformity. RESULTS: Systemic blood pressure was similar in young and middle aged men (YM: 118 ± 4mmHg vs MAM: 122 ± 4mmHg, p > 0.05), while echocardiographic estimates of pulmonary blood pressure via the tricuspid regurgitation pressure gradient were greater in middle aged men (YM: 17 ± 4mmHg vs MAM: 25 ± 6mmHg, p < 0.05). LV and RV dimensions were similar (p > 0.05) in young (LV EDV: 118 ± 19mL; RV EDA: 18.3 ± 2.2cm2) and middle aged men (LV EDV: 118 ± 17mL; RV EDA: 17.3 ± 3.8cm2). LV global longitudinal strain (YM: -17.5 ± 1.0% vs MAM: -18.0 ± 1.0%, p > 0.05) was similar in young and middle aged men, while RV global longitudinal strain (YM: -27.3 ± 1.8% vs MAM: -22.5 ± 1.7%, p<0.01) was lower in middle aged men. LV transmural strain gradient (YM: -4.6 ± 0.4% vs MAM: -4.6 ± 0.4%, p > 0.05) was similar in young and middle aged men, while RV transmural strain gradient (YM: -1.1 ± 0.4% vs MAM: -5.5 ± 0.5%, p<0.01) was higher in middle aged men. CONCLUSION: Ageing was associated with global and regional alterations in RV myocardial mechanics, while LV function was unaltered. Specifically, ageing resulted in a decrease in RV global strain and an increase in transmural non-uniformity (i.e., increased transmural strain gradient). Differences in LV and RV myocardial architecture and age-related changes in the pulmonary vasculature are possible explanations for opposing LV and RV functional remodeling in response to ageing.
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    Conference Title
    Medicine & Science in Sports & Exercise
    Volume
    50
    Issue
    5S
    DOI
    https://doi.org/10.1249/01.mss.0000535707.60308.15
    Subject
    Human Movement and Sports Sciences
    Medical Physiology
    Public Health and Health Services
    Science & Technology
    Life Sciences & Biomedicine
    Sport Sciences
    Publication URI
    http://hdl.handle.net/10072/403204
    Collection
    • Conference outputs

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