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dc.contributor.authorStewart, Glenn
dc.contributor.authorJohnson, Bruce
dc.contributor.authorBalmain, Bryce
dc.contributor.authorShino, Kenji
dc.contributor.authorYamada, Akira
dc.contributor.authorMorris, Norman
dc.contributor.authorChan, Jonathan
dc.contributor.authorSabapathy, Surendran
dc.date.accessioned2021-03-17T01:56:48Z
dc.date.available2021-03-17T01:56:48Z
dc.date.issued2018
dc.identifier.issn0195-9131
dc.identifier.doi10.1249/01.mss.0000535707.60308.15
dc.identifier.urihttp://hdl.handle.net/10072/403204
dc.description.abstractIntroduction: Ageing is associated with a progressive stiffening of the pulmonary vasculature that causes an increase in pulmonary vascular resistance and a decrease in compliance. It remains unclear if right ventricular myocardial mechanics adapt in response to age-related remodeling in the pulmonary vasculature. PURPOSE: Accordingly, this study examined global and transmural longitudinal myocardial tissue deformation (strain) in a cohort of healthy young and middle-aged men to characterize age-related changes in myocardial tissue mechanics. METHODS: Two-dimensional echocardiography was used to measure left (LV) and right (RV) ventricular strain in 10 young men (YM; Age: 27 ± 2yr, BMI: 23.2 ± 2.4m2) and 10 middle aged men (MAM; Age: 61 ± 7yr, BMI: 25.9 ± 3.2m2). A transmural strain gradient was calculated as the difference between endocardial and epicardial strain as an index of regional non-uniformity. RESULTS: Systemic blood pressure was similar in young and middle aged men (YM: 118 ± 4mmHg vs MAM: 122 ± 4mmHg, p > 0.05), while echocardiographic estimates of pulmonary blood pressure via the tricuspid regurgitation pressure gradient were greater in middle aged men (YM: 17 ± 4mmHg vs MAM: 25 ± 6mmHg, p < 0.05). LV and RV dimensions were similar (p > 0.05) in young (LV EDV: 118 ± 19mL; RV EDA: 18.3 ± 2.2cm2) and middle aged men (LV EDV: 118 ± 17mL; RV EDA: 17.3 ± 3.8cm2). LV global longitudinal strain (YM: -17.5 ± 1.0% vs MAM: -18.0 ± 1.0%, p > 0.05) was similar in young and middle aged men, while RV global longitudinal strain (YM: -27.3 ± 1.8% vs MAM: -22.5 ± 1.7%, p<0.01) was lower in middle aged men. LV transmural strain gradient (YM: -4.6 ± 0.4% vs MAM: -4.6 ± 0.4%, p > 0.05) was similar in young and middle aged men, while RV transmural strain gradient (YM: -1.1 ± 0.4% vs MAM: -5.5 ± 0.5%, p<0.01) was higher in middle aged men. CONCLUSION: Ageing was associated with global and regional alterations in RV myocardial mechanics, while LV function was unaltered. Specifically, ageing resulted in a decrease in RV global strain and an increase in transmural non-uniformity (i.e., increased transmural strain gradient). Differences in LV and RV myocardial architecture and age-related changes in the pulmonary vasculature are possible explanations for opposing LV and RV functional remodeling in response to ageing.
dc.languageEnglish
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofconferencenameAnnual Meeting of the American College of Sports Medicine (ACSM)
dc.relation.ispartofconferencetitleMedicine & Science in Sports & Exercise
dc.relation.ispartofdatefrom2018-05-29
dc.relation.ispartofdateto2018-06-02
dc.relation.ispartoflocationMinneapolis, MN
dc.relation.ispartofpagefrom189
dc.relation.ispartofpageto189
dc.relation.ispartofissue5S
dc.relation.ispartofvolume50
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode3208
dc.subject.fieldofresearchcode3202
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsSport Sciences
dc.titleAgeing Alters Right Ventricular But Not Left Ventricular Myocardial Mechanics
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dcterms.bibliographicCitationStewart, G; Johnson, B; Balmain, B; Shino, K; Yamada, A; Morris, N; Chan, J; Sabapathy, S, Ageing Alters Right Ventricular But Not Left Ventricular Myocardial Mechanics, Medicine & Science in Sports & Exercise, 2018, 50 (5), pp. 189-189
dc.date.updated2021-03-17T01:54:40Z
gro.hasfulltextNo Full Text
gro.griffith.authorSabapathy, Surendran
gro.griffith.authorChan, Jonathan H.
gro.griffith.authorMorris, Norman


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