dc.contributor.author | Stewart, Glenn | |
dc.contributor.author | Johnson, Bruce | |
dc.contributor.author | Balmain, Bryce | |
dc.contributor.author | Shino, Kenji | |
dc.contributor.author | Yamada, Akira | |
dc.contributor.author | Morris, Norman | |
dc.contributor.author | Chan, Jonathan | |
dc.contributor.author | Sabapathy, Surendran | |
dc.date.accessioned | 2021-03-17T01:56:48Z | |
dc.date.available | 2021-03-17T01:56:48Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0195-9131 | |
dc.identifier.doi | 10.1249/01.mss.0000535707.60308.15 | |
dc.identifier.uri | http://hdl.handle.net/10072/403204 | |
dc.description.abstract | Introduction: Ageing is associated with a progressive stiffening of the pulmonary vasculature that causes an increase in pulmonary vascular resistance and a decrease in compliance. It remains unclear if right ventricular myocardial mechanics adapt in response to age-related remodeling in the pulmonary vasculature.
PURPOSE: Accordingly, this study examined global and transmural longitudinal myocardial tissue deformation (strain) in a cohort of healthy young and middle-aged men to characterize age-related changes in myocardial tissue mechanics.
METHODS: Two-dimensional echocardiography was used to measure left (LV) and right (RV) ventricular strain in 10 young men (YM; Age: 27 ± 2yr, BMI: 23.2 ± 2.4m2) and 10 middle aged men (MAM; Age: 61 ± 7yr, BMI: 25.9 ± 3.2m2). A transmural strain gradient was calculated as the difference between endocardial and epicardial strain as an index of regional non-uniformity.
RESULTS: Systemic blood pressure was similar in young and middle aged men (YM: 118 ± 4mmHg vs MAM: 122 ± 4mmHg, p > 0.05), while echocardiographic estimates of pulmonary blood pressure via the tricuspid regurgitation pressure gradient were greater in middle aged men (YM: 17 ± 4mmHg vs MAM: 25 ± 6mmHg, p < 0.05). LV and RV dimensions were similar (p > 0.05) in young (LV EDV: 118 ± 19mL; RV EDA: 18.3 ± 2.2cm2) and middle aged men (LV EDV: 118 ± 17mL; RV EDA: 17.3 ± 3.8cm2). LV global longitudinal strain (YM: -17.5 ± 1.0% vs MAM: -18.0 ± 1.0%, p > 0.05) was similar in young and middle aged men, while RV global longitudinal strain (YM: -27.3 ± 1.8% vs MAM: -22.5 ± 1.7%, p<0.01) was lower in middle aged men. LV transmural strain gradient (YM: -4.6 ± 0.4% vs MAM: -4.6 ± 0.4%, p > 0.05) was similar in young and middle aged men, while RV transmural strain gradient (YM: -1.1 ± 0.4% vs MAM: -5.5 ± 0.5%, p<0.01) was higher in middle aged men.
CONCLUSION: Ageing was associated with global and regional alterations in RV myocardial mechanics, while LV function was unaltered. Specifically, ageing resulted in a decrease in RV global strain and an increase in transmural non-uniformity (i.e., increased transmural strain gradient). Differences in LV and RV myocardial architecture and age-related changes in the pulmonary vasculature are possible explanations for opposing LV and RV functional remodeling in response to ageing. | |
dc.language | English | |
dc.publisher | Lippincott Williams & Wilkins | |
dc.relation.ispartofconferencename | Annual Meeting of the American College of Sports Medicine (ACSM) | |
dc.relation.ispartofconferencetitle | Medicine & Science in Sports & Exercise | |
dc.relation.ispartofdatefrom | 2018-05-29 | |
dc.relation.ispartofdateto | 2018-06-02 | |
dc.relation.ispartoflocation | Minneapolis, MN | |
dc.relation.ispartofpagefrom | 189 | |
dc.relation.ispartofpageto | 189 | |
dc.relation.ispartofissue | 5S | |
dc.relation.ispartofvolume | 50 | |
dc.subject.fieldofresearch | Sports science and exercise | |
dc.subject.fieldofresearch | Medical physiology | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 4207 | |
dc.subject.fieldofresearchcode | 3208 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Sport Sciences | |
dc.title | Ageing Alters Right Ventricular But Not Left Ventricular Myocardial Mechanics | |
dc.type | Conference output | |
dc.type.description | E3 - Conferences (Extract Paper) | |
dcterms.bibliographicCitation | Stewart, G; Johnson, B; Balmain, B; Shino, K; Yamada, A; Morris, N; Chan, J; Sabapathy, S, Ageing Alters Right Ventricular But Not Left Ventricular Myocardial Mechanics, Medicine & Science in Sports & Exercise, 2018, 50 (5), pp. 189-189 | |
dc.date.updated | 2021-03-17T01:54:40Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Sabapathy, Surendran | |
gro.griffith.author | Chan, Jonathan H. | |
gro.griffith.author | Morris, Norman | |