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  • Benefits of Immediate Versus Delayed Exercise in Men Initiating ADT for Prostate Cancer

    Author(s)
    Taaffe, Dennis R
    Newton, Robert U
    Spry, Nigel
    Joseph, David
    Chambers, Suzanne K
    Gardiner, Robert A
    Cormie, Prue
    Shum, David HK
    Galvao, Daniel A
    Griffith University Author(s)
    Gardiner, Robert A.
    Chambers, Suzanne K.
    Shum, David
    Year published
    2018
    Metadata
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    Abstract
    PURPOSE: To examine whether it was more efficacious to commence exercise at the onset of ADT rather than later in treatment to counter declines in strength and physical function. METHODS: One hundred and four men with PCa (68.3±7.0 years, 29.7±5.2 % fat, Gleason score 7.6±0.9) initiating ADT were randomised to immediate exercise (EX, n=54) or delayed exercise (DEL, n=50) for 12 months. EX comprised 6 months of supervised resistance/aerobic/impact exercise initiated at onset of ADT with 6-month follow-up. DEL comprised 6 months usual care followed by 6 months of resistance/aerobic/impact exercise. Muscle strength (chest ...
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    PURPOSE: To examine whether it was more efficacious to commence exercise at the onset of ADT rather than later in treatment to counter declines in strength and physical function. METHODS: One hundred and four men with PCa (68.3±7.0 years, 29.7±5.2 % fat, Gleason score 7.6±0.9) initiating ADT were randomised to immediate exercise (EX, n=54) or delayed exercise (DEL, n=50) for 12 months. EX comprised 6 months of supervised resistance/aerobic/impact exercise initiated at onset of ADT with 6-month follow-up. DEL comprised 6 months usual care followed by 6 months of resistance/aerobic/impact exercise. Muscle strength (chest press, leg press, seated row) and physical performance (6-m usual and fast walk, 6-m backwards walk, 400-m walk, stair climb, repeated chair rise) were assessed at baseline, 6 and 12 months. Data were analysed by ANCOVA using an intention-to-treat approach. RESULTS: There was a significant difference for all strength measures at 6 months favouring EX (p<0.001), with net differences in leg press, seated row and chest press strength of 19.9 kg (95% CI, 12.3 to 27.5 kg), 5.6 kg (3.8 to 7.4 kg), and 4.3kg (2.7 to 5.8 kg), respectively. From 6-12 months DEL increased in all strength measures (p<0.001) such that there were no differences between groups at 12 months. Similarly, physical performance improved (p<0.001) in EX compared to DEL at 6 months for the 400-m walk (-9.7 s, 95% CI -14.8 to -4.6 s), stair climb (-0.4 s, -0.6 to -0.2 s) and chair rise (-1.0 s, -1.4 to -0.7 s), with no differences between groups by 12 months. CONCLUSION: Exercise either at the onset or after 6 months ADT preserves/enhances muscle strength and physical function. However, to avoid any initial treatment-related adverse effects on strength and function, exercise should be prescribed and commenced at the onset of ADT.
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    Conference Title
    Medicine & Science in Sports & Exercise
    Volume
    50
    Issue
    5S
    DOI
    https://doi.org/10.1249/01.mss.0000536351.44823.34
    Subject
    Human Movement and Sports Sciences
    Medical Physiology
    Public Health and Health Services
    Science & Technology
    Life Sciences & Biomedicine
    Sport Sciences
    Publication URI
    http://hdl.handle.net/10072/403205
    Collection
    • Conference outputs

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