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dc.contributor.authorKomarova, T
dc.contributor.authorMcKeating, D
dc.contributor.authorPerkins, AV
dc.contributor.authorTinggi, U
dc.date.accessioned2021-03-18T06:22:17Z
dc.date.available2021-03-18T06:22:17Z
dc.date.issued2021
dc.identifier.issn1661-7827
dc.identifier.doi10.3390/ijerph18052652
dc.identifier.urihttp://hdl.handle.net/10072/403274
dc.description.abstractThe levels of trace elements in whole blood and plasma have been widely used for assessing nutritional status and monitoring exposure and can vary widely in populations from different geographical regions. In this study, whole blood samples (n = 120) and plasma samples (n = 120) were obtained from healthy donors attending the Red Cross Blood Bank (Queensland Red Cross Blood Service), which provided information for age and sex. There were 71 males (age range: 19–73 years) and 49 females (age range: 18–72 years) for whole blood samples, and 59 males (age range: 19–81 years) and 61 females (age range: 19–73 years) for plasma samples. The main aim of the study was to provide information on blood reference levels of 21 trace elements (Ag, Al, As, Bi, Br, Cd, Co, Cr, Cu, Hg, I, Mn, Mo, Ni, Pb, Sb, Se, Tl, U, V, Zn) in Queensland. The study also aimed to assess differences in trace element blood levels between males and females and the effect of age. The trace element levels in blood samples were analysed using inductively coupled plasma mass spectrometry (ICP-MS) and the standard reference materials of Seronorm (Trace Elements Whole Blood) and UTAK (Trace Elements Serum) were used for quality control and assurance. The study found wide variations of trace element levels in whole blood and plasma, and generally the levels were comparable to other countries. No detectable levels were found for Bi, Cr, U and V in whole blood, but V levels were found in plasma samples. There were significant differences between males and females for whole blood Cu (p < 0.001), I (p = 0.009), Tl (p = 0.016) and Zn (p = 0.016). Significant differences were also found for plasma Cu (p < 0.001) and Se (p = 0.003) between males and females. There were trends of increased levels of blood Pb, Se and Zn with age. The study has provided further information on a wide range of trace elements in blood as reference levels for Queensland and Australia which are currently lacking.
dc.description.peerreviewedYes
dc.languageen
dc.publisherMDPI AG
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto15
dc.relation.ispartofissue5
dc.relation.ispartofjournalInternational Journal of Environmental Research and Public Health
dc.relation.ispartofvolume18
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.titleTrace element analysis in whole blood and plasma for reference levels in a selected queensland population, Australia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKomarova, T; McKeating, D; Perkins, AV; Tinggi, U, Trace element analysis in whole blood and plasma for reference levels in a selected queensland population, Australia, International Journal of Environmental Research and Public Health, 2021, 18 (5), pp. 1-15
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-03-18T06:16:09Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorMcKeating, Daniel R.


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